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Healthcare
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Neuroprotective Strategies for Dry Eye Disease
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Neuroprotective Strategies for Dry Eye Disease

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 5385

Special Issue Editor

Dr. Flavia Leao Barbosa

E-Mail Website
Guest Editor
Department of Ophthalmology, Tufts Medical Center, Boston, MA 02111, USA
Interests: dry eye; cornea; conjunctiva; goblet cells; trophic factors

Special Issue Information

Dear Colleagues,

Dry eye is defined as the “multifactorial of the ocular surface characterized by a loss of homeostasis of the tear film instability and hyperosmolarity, ocular surface inflammation and damage, and neurosensory abnormalities play etiological roles”. Much interest has centered around dry eye disease in the past few years, and it is estimated that over 16 million adults in the USA alone suffer from dry eye disease. Neurotrophic factors are secreted by abundant nerve fibers, which are important for the maintenance and repair of cornea. In recent decades, the role of neuropeptides has been elucidated in the pathophysiology of diseases. It is considered that decreased corneal nerve fiber density after corneal injury contributes to the delayed repair effect because of the loss of trophic influences.
In this Special Issue of Healthcare, we are seeking articles that provide new insights into the understanding of the neurochemistry, trophic factors and therapeutic potential for treatments including molecular and cellular mechanisms involved in the initiation and perpetuation of inflammation. 

Dr. Flavia Leao Barbosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dry eye
  • neuropeptides
  • corneal nerves
  • inflammation
  • animal models
  • therapies

Published Papers (3 papers)

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Research

7 pages, 528 KiB  
Article
Measurements of Tear Evaporation Rate in Subjects with Refractive Errors Using a Portable Evaporimeter
by Raied Fagehi, Gamal A. El-Hiti, Mushawwat H. Alsubaie, Ali Abusharha, Mana A. Alanazi, Ali M. Masmali and Turki Almubrad
Healthcare 2022, 10(2), 405; https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare10020405 - 21 Feb 2022
Cited by 9 | Viewed by 1550
Abstract
Dry eye symptoms are associated with refractive errors. We aimed to measure the tear evaporation rate (TER) in subjects with refractive errors (RE) using a portable evaporimeter. This nonrandomized, case–control, and observational study included 75 subjects, including 25 subjects aged 18–38 years (28.8 [...] Read more.
Dry eye symptoms are associated with refractive errors. We aimed to measure the tear evaporation rate (TER) in subjects with refractive errors (RE) using a portable evaporimeter. This nonrandomized, case–control, and observational study included 75 subjects, including 25 subjects aged 18–38 years (28.8 ± 6.8 years) with myopia (−0.75 to −3.75 D) and 25 subjects aged 18–39 years (27.7 ± 5.5 years) with hyperopia (+0.50 to +3.75 D). In addition, a control group of 25 subjects with emmetropic eyes aged 20–30 years (23.6 ± 2.6 years) was recruited. The ocular surface disease index (OSDI) was completed, followed by the TER measurements using a portable evaporimeter. The OSDI score and TER measurements showed dry eye symptoms in 36% and 48% of myopic subjects, respectively. For hyperopic participants, dry eye was observed in 24% and 56% of the subjects based on the OSDI and TER scores, respectively. Significant differences (Mann-Whitney U test; p < 0.001) were found among the OSDI and TER scores recorded within the study (myopic and hyperopic subjects) and control groups. Significant strong positive correlations were detected between the OSDI and TER scores in both myopic (p = 0.004; r = 0.559) and hyperopic (p = 0.001; r = 0.619) subjects. The TER scores were significantly higher in subjects with RE (myopic and hyperopic) as compared with individuals with normal eyes. Full article
(This article belongs to the Special Issue Neuroprotective Strategies for Dry Eye Disease)
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8 pages, 571 KiB  
Article
Evaluation of Tear Evaporation Rate in Patients with Diabetes Using a Hand-Held Evaporimeter
by Ali Abusharha, Gamal A. El-Hiti, Mushawwat H. Alsubaie, Abdulaziz F. Munshi, Ahmed R. Alnasif, Raied Fagehi, Mana A. Alanazi and Ali M. Masmali
Healthcare 2022, 10(1), 104; https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare10010104 - 05 Jan 2022
Cited by 4 | Viewed by 1374
Abstract
Diabetes is a very common disease and is considered a risk factor for many diseases such as dry eye. The aim of the current work was to evaluate the tear evaporation rate (TER) in patients with diabetes using a hand-held evaporimeter. This observational, [...] Read more.
Diabetes is a very common disease and is considered a risk factor for many diseases such as dry eye. The aim of the current work was to evaluate the tear evaporation rate (TER) in patients with diabetes using a hand-held evaporimeter. This observational, case–control and non-randomized study included 30 male patients with diabetes (17 controlled and 13 uncontrolled) with a mean ± standard deviation (SD) of 33.1 ± 7.9 years. An age-matched (18–43 years; 32.2 ± 6.5 years) control group consisting of 30 male subjects was also enrolled for comparison. Subjects with thyroid gland disorder, a high body mass index, high blood cholesterol, or thalassemia, contact lens wearers, and smokers were excluded. The TER was measured after the completion of the ocular surface disease index (OSDI) by each participant. The OSDI and TER median scores were significantly (Wilcoxon test, p < 0.05) higher in patients with diabetes (median (interquartile range; IQR) = 12.0 (8.3) and 46.4 (36.7) g/m2h, respectively) compared to the subjects within the control group (5.6 (7.0) and 15.1 (11.9) g/m2h, respectively). The median scores for the OSDI and TER measurements were significantly (Wilcoxon test, p < 0.05) higher among uncontrolled diabetes patients (13.0 (11.5) and 53.4 (14.2) g/m2h, respectively) compared to those obtained for patients with controlled diabetes (11.0 (8.0) and 27.3 (32.6) g/m2h, respectively). The tear evaporation rate in patients with diabetes was significantly higher compared to those obtained in subjects without diabetes. Uncontrolled diabetes patients have a higher tear evaporation rate compared to controlled diabetes patients. Therefore, diabetes can lead to eye dryness, since these patients possibly suffer excessive tear evaporation. Full article
(This article belongs to the Special Issue Neuroprotective Strategies for Dry Eye Disease)
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16 pages, 2022 KiB  
Article
Risk of Dry Eye Syndrome in Patients with Orbital Fracture: A Nationwide Population-Based Cohort Study
by Cindy Yi-Yu Hsu, Junior Chun-Yu Tu, Chi-Hsiang Chung, Chien-An Sun, Wu-Chien Chien and Hsin-Ting Lin
Healthcare 2021, 9(5), 605; https://0-doi-org.brum.beds.ac.uk/10.3390/healthcare9050605 - 18 May 2021
Viewed by 1676
Abstract
This study aimed to investigate whether orbital fracture increases the risk of dry eye syndrome (DES) and identified the profile of prognostic factors. We studied a cohort from the Taiwan National Health Insurance Research Database (NHIRD). Overall, 46,179 and 184,716 participants were enrolled [...] Read more.
This study aimed to investigate whether orbital fracture increases the risk of dry eye syndrome (DES) and identified the profile of prognostic factors. We studied a cohort from the Taiwan National Health Insurance Research Database (NHIRD). Overall, 46,179 and 184,716 participants were enrolled in the study and control groups, respectively. Each patient in the case group was age- and gender-matched to four individuals without orbital fracture that served as the control group. Cox proportional hazards analysis regression was used to estimate the risks of incident DES. During the follow-up period, the case group was more likely to develop incident DES (0.17%) than the control group (0.11%) (p = 0.001). Multivariate Cox regression analysis demonstrated that the case group had a 4.917-fold increased risk of DES compared to the controls. In the stratified age group, orbital fracture had the highest impact on patients aged 18–29 years. Furthermore, patients with orbital roof fracture have a greater risk of developing DES. Regardless of whether having received surgery or not, the patients with orbital fracture have higher risks of DES. Our study demonstrated that orbital fracture increases the risk of developing subsequent DES. Early recognition by thorough examinations with raised awareness in the clinical setting could preserve visual function and prevent further complications. Full article
(This article belongs to the Special Issue Neuroprotective Strategies for Dry Eye Disease)
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