Special Issue "Myocardial Fibrogenesis—Aetiology, Pathophysiology, Therapeutic Strategies"

A special issue of Hearts (ISSN 2673-3846).

Deadline for manuscript submissions: closed (28 February 2021).

Special Issue Editors

Dr. Gabriela Kania
E-Mail Website
Guest Editor
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zürich, Wagistrasse 14, 8952 Schlieren, Switzerland
Interests: mechanism of multiorgan remodeling; heart pathogenesis; fibrosis; fibroblast; arrhythmia; conduction system; 3D cardiac models; systemic sclerosis; heart dysfunction
Special Issues and Collections in MDPI journals
Dr. Przemyslaw Blyszczuk
E-Mail Website
Guest Editor
Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland
Interests: myocarditis; inflammatory dilated cardiomyopathy; innate and adaptive immunity; mouse models of heart failure; myocardial inflammation; Wnt signaling
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease affects 26 million adults worldwide and represents the number one cause of death globally. Heart failure (HF)—a chronic, progressive condition characterized by impaired pumping ability of the heart muscle—represents an outcome of various cardiovascular diseases. Despite the progress in the treatment of HF, prevalence and hospitalization rates are constantly increasing, and the outlook remains unfavorable. HF is frequently associated with cardiac fibrosis and immunofibrotic processes. Cardiac fibrosis reflects exaggerated accumulation of stromal cells and extracellular matrix components in the tissue and develops following major ischemic events in the heart, mainly as a reparative process but occurs also in a number of non-ischemic cardiac disorders as a response to increased blood pressure or following systemic or heart-specific inflammation. Understanding the cellular and molecular bases of cardiac fibrogenesis is crucial for identifying potential diagnostic and therapeutic targets in cardiovascular diseases.

In this Special Issue, we encourage the submission of manuscripts describing the mechanisms driving myocardial fibrosis, the cellular source of pathological cardiac myofibroblasts, the impact of myocardial fibrosis on heart dysfunctions, and novel animal and 3D systems modeling human cardiac pathology. We are also highly interested in manuscripts reporting application of preclinical and clinical antifibrotic strategies. Furthermore, studies on the specific signaling pathways responsible for cardiac fibroblast activation, proliferation and fibroblast–myofibroblast transition following the myocardial injury, as well as reports describing immune cell–fibroblast cross-talk in the injured myocardium are within the scope of this Special Issue.

Topics of interests:

  • Etiology of myocardial fibrosis
  • Fibrosis effects on heart dysfunction
  • Cellular sources of cardiac fibroblasts
  • Contribution of immune cells to pathological cardiac remodeling
  • Molecular signaling controlling myocardial fibrosis
  • Animal models of myocardial fibrosis
  • 3D in vitro models of cardiac fibrosis

Dr. Gabriela Kania
Dr. Przemyslaw Blyszczuk
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Hearts is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Myocardial fibrosis 
  • Mechanism of myocardial fibrosis 
  • Cardiac fibroblasts progenitors 
  • Animal models 
  • 3D models

Published Papers

There is no accepted submissions to this special issue at this moment.
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