Antimicrobial Resistance and Stewardship in the Time of COVID-19 Pandemic

A special issue of Infectious Disease Reports (ISSN 2036-7449).

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 4460

Special Issue Editors


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Guest Editor
Clinical and Research Department, National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy
Interests: Clostridioides difficile infection; antimicrobial resistance; antimicrobial treatment; immune response; host-pathogen interaction; human gut microbiota; infection control
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Guest Editor
Infection Prevention & Control and Infectious Disease Unit, University Hospital "Campus Bio-Medico", 00128 Rome, Italy
Interests: severe infections; infective endocarditis; emerging infections; infections in transplanted patients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since 31 December 2019, the world has been shaken by the most profound health crisis of the last several decades. The coronavirus disease 2019 (COVID-19) rapidly became a pandemic, testing the resilience of health systems worldwide. Especially in critical areas, healthcare facilities suddenly faced high numbers of hospitalizations, shortages of beds, and the need to protect healthcare workers from COVID-19. The novelty and rapid spread of COVID-19 combined with the lack of high-level evidence on COVID-19 management led to the adoption of heterogeneous approaches and, probably, less attention being paid to the prevention of other bacterial infections.

The first available recommendations on the management of COVID-19 patients considered the use of empirical antibiotic treatment, resulting in a large use of antimicrobials. Therefore, compliance with antibiotic stewardship programs has been challenged during the pandemic.

Currently, we do not yet have a clear picture of the impact of the COVID-19 pandemic on compliance with antibiotic stewardship programs and the prevalence of multidrug-resistant bacterial infection.

The focus of this Special Issue includes any aspects concerning antimicrobial stewardship, infection control, and multidrug-resistant bacterial infections during the COVID-19 pandemic.

A better definition of the effect of infection control on the incidence of multidrug-resistant bacterial infection will be essential to improving the management of COVID-19 patients.

Dr. Guido Granata
Dr. Nicola Petrosillo
Guest Editors

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Keywords

  • multidrug-resistant bacterial infection
  • antibiotic stewardship
  • COVID-19
  • infection control
  • antibiotics

Published Papers (1 paper)

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Research

11 pages, 1850 KiB  
Article
Bacterial and Fungal Co-Infections and Superinfections in a Cohort of COVID-19 Patients: Real-Life Data from an Italian Third Level Hospital
by Manuela Ceccarelli, Andrea Marino, Sarah Pulvirenti, Viviana Coco, Barbara Busà, Giuseppe Nunnari and Bruno Santi Cacopardo
Infect. Dis. Rep. 2022, 14(3), 372-382; https://0-doi-org.brum.beds.ac.uk/10.3390/idr14030041 - 12 May 2022
Cited by 10 | Viewed by 2896
Abstract
The use of immune suppressive drugs combined with the natural immune suppression caused by SARS-CoV-2 can lead to a surge of secondary bacterial and fungal infections. The aim of this study was to estimate the incidence of superinfections in hospitalized subjects with COVID-19. [...] Read more.
The use of immune suppressive drugs combined with the natural immune suppression caused by SARS-CoV-2 can lead to a surge of secondary bacterial and fungal infections. The aim of this study was to estimate the incidence of superinfections in hospitalized subjects with COVID-19. We carried out an observational retrospective single center cohort study. We enrolled patients admitted at the “Garibaldi” hospital for ≥72 h, with a confirmed diagnosis of COVID-19. All patients were routinely investigated for bacterial, viral, and fungal pathogens. A total of 589 adults with COVID-19 were included. A total of 88 infections were documented in different sites among 74 patients (12.6%). As for the etiology, 84 isolates were bacterial (95.5%), while only 4 were fungal (4.5%). A total of 51 episodes of hospital-acquired infections (HAI) were found in 43 patients, with a bacterial etiology in 47 cases (92.2%). Community-acquired infections (CAIs) are more frequently caused by Streptococcus pneumoniae, while HAIs are mostly associated with Pseudomonas aeruginosa. A high rate of CAIs and HAIs due to the use of high-dose corticosteroids and long hospital stays can be suspected. COVID-19 patients should be routinely evaluated for infection and colonization. More data about antimicrobial resistance and its correlation with antibiotic misuse in COVID-19 patients are required. Full article
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