Special Issue "Tackling Cancer Stem Cells and Their Involvement in Therapy Resistance"

Special Issue Editors

Dr. Joanna B. Grabarek
E-Mail Website
Guest Editor
Drug Discovery Unit Cancer Research U.K. Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, United Kingdom
Interests: developmental biology; Stem cells; differentiation mechanisms; cancer research; drug development
Dr. Daphné Brisard
E-Mail Website
Guest Editor
Molecular oncology department, Drug discovery unit, Cancer Research U.K. Manchester Institute, The University of Manchester, Alderley Park, SK10 4TG, United Kingdom
Interests: cancer stem cells; breast cancer; melanoma; drug discovery; 3D assays

Special Issue Information

Dear Colleagues,

Many advances have been achieved in treating patients afflicted with cancer but, in many cases, a relapse is concomitantly observed with resistance to therapy. Cancer stem cells are a small cell population that have the ability to self-renew and produce new tumors, and are resistance to therapy. They are involved in invasion and metastasis, which are some of the hallmarks of cancer. Consequently, cancer stem cells have been incriminated in the recurrence observed in patients. We must better understand how they function, the pathways upon which they rely, and the metabolic features for each cancer. To study them, more accurate markers must be defined, which remains challenging for some cancers. All the above are fundamental for advances in designing specific cancer stem cell inhibitors, including that could be used in combination with standard of care treatments for more precise medicine.

This Special Issue aims to highlight the latest discoveries in treating and understanding the ruling mechanisms in the cancer stem cell research field.

Dr. Joanna B. Grabarek
Dr. Daphné Brisard
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cancer stem cells
  • Cancer treatment
  • Therapy resistance
  • Targeted therapy
  • Stem cell markers

Published Papers

This special issue is now open for submission.
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