Journal Browser

► Journal Browser

Special Issue Information

Dear Colleagues,

Fifty years on since we first started organizing screening programs in Western countries, cervical cancer is still the fourth most common cancer among women worldwide. Additionally, while the incidence has decreased dramatically in Western countries over the last few decades, cervical cancer is still a major problem in developing countries. One of the major breakthroughs since the 1970s was the implementation of HPV testing in cervical cancer screening.

This Special Issue of the International Journal of Environmental Research and Public Health will cover the whole spectrum of cervical cancer screening from the first approaches to screening in developing countries to the implementation of new triage instruments in established organized screening programs. Manuscripts on alternative screening instruments such as cervicovaginal self-sampling or HPV testing in urine are welcome, as well as studies on screening concepts for cervical cancer hotspots. Original articles can be submitted as well as systematic reviews, meta-analyses or modeling studies on the various aspects of this topic.

Dr. Matthias Jentschke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

cervical cancer screening
HPV
self-sampling
cytology
organized screening program
public health

Published Papers (2 papers)

Download All Papers

Research

8 pages, 307 KiB

Open AccessArticle

CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection

by Faruk Cem Ertik, Johanna Kampers, Fabienne Hülse, Claudia Stolte, Gerd Böhmer, Peter Hillemanns and Matthias Jentschke

Int. J. Environ. Res. Public Health 2021, 18(19), 10388; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910388 - 02 Oct 2021

Cited by 13 | Viewed by 2432

Abstract

High-risk human papillomavirus (hr-HPV) infection of the cervicovaginal tract is known to be the major cause of cervical cancer. Similar to various other countries, Germany introduced an organized combined screening including cytology and HPV testing in 2020. The participation rate was around 70% in the past. Self-testing for hr-HPV infections could be an option to increase the participation rate. Two dry vaginal self-sampling devices and a device for the self-collection of first-void urine were evaluated in combination with a PCR-based hr-HPV test regarding their clinical performance (sensitivity for high-grade cervical intraepithelial neoplasia, CIN 2+). A cervical smear taken by a clinician during colposcopy was used as reference. This open prospective multicenter trial recruited patients referred to the two participating colposcopy clinics (Hannover Medical School and IZD Hannover, Germany) with abnormal results from cervical cancer screening from 05/2020 to 11/2020. All patients received three CE-certified self-sampling devices (FLOQSwabs, COPAN, Italy; Evalyn Brush, Rovers Medical Devices, the Netherlands; Colli-Pee FV-5000, Novosanis, Wijnegem, Belgium) with instructions to read and apply at home in a pre-specified alternating order without medical assistance. HPV testing was performed after adequate preservation and DNA extraction. Histological results from colposcopy or cervical excisional surgery after self-sampling were used as the gold-standard. The data of 65 patients were analyzed. All invasive cancer cases and over 90% of the CIN 3 lesions were found to be hr-HPV positive with all three self-collection devices. All devices were considered easy to use without any difficulties following the written instructions. Hr-HPV testing of self-collected first-void urine and dry vaginal self-samples showed a high sensitivity for CIN 3+ comparable to that of a clinician-taken smear. Self-sampling was well accepted as it is convenient and easy to use. Full article

(This article belongs to the Special Issue Cervical Cancer Screening and Prevention)

8 pages, 284 KiB

Open AccessArticle

HIV-Infected Women with Low-Grade Squamous Intraepithelial Lesion on Cervical Cytology Have Higher Risk of Underlying High-Grade Cervical Intraepithelial Neoplasia

by Nawin Sakdadech, Tanarat Muangmool and Jatupol Srisomboon

Int. J. Environ. Res. Public Health 2021, 18(19), 10211; https://doi.org/10.3390/ijerph181910211 - 28 Sep 2021

Cited by 2 | Viewed by 1519

Abstract

Objective: To evaluate the risk of histological high-grade cervical lesions defined as cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women with human immunodeficiency virus (HIV) infection who had low-grade squamous intraepithelial lesions (LSIL) on cervical cytological screening compared with HIV-uninfected women who had similar cytology. Methods: 127 HIV-positive women aged 18–65 years with LSIL cytology undergoing colposcopic examination between January 2008 and December 2019 at Chiang Mai University Hospital were reviewed. By matching 1:1 ratio for age (±5 years) and examination time period (±12 months), 127 HIV-negative women with LSIL cytology in the same period were recruited as controlled subjects for comparison. The patients’ characteristics, HIV status, CD4 counts, antiretroviral therapy, and histopathology on cervical biopsy were analyzed. Results: HIV-infected women significantly had early sexual debut (age < 20 years) and more sexual partners (≥2) than HIV-uninfected women. The risk of underlying CIN2+ in HIV-infected women was significantly higher than that in HIV-negative women (20.5% vs. 9.4%, p = 0.021) with an odds ratio (OR) of 2.47 and 95% confidence interval (CI) = 1.18–5.14. After adjustment, the risk of underlying CIN2+ in HIV-infected women remained significantly higher than that in HIV-uninfected women (adjusted OR = 2.55, 95% CI = 1.11–5.82, p = 0.027). Conclusion: Among women with LSIL on cervical cytology, the risk of underlying CIN2+ in HIV-infected women was approximately 2.5 times higher than those without HIV infection. Colposcopy is indicated particularly in the case of women with a long duration of HIV infection. Full article

(This article belongs to the Special Issue Cervical Cancer Screening and Prevention)

Journal Menu

Journal Browser

Cervical Cancer Screening and Prevention

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (2 papers)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI