Special Issue "Gender Differences in Mood Disorders during the Lifespan: Towards a Precision Medicine"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Women's Health".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Marta Serati
E-Mail Website
Guest Editor
Department of Mental Health, ASST RHODENSE, 20024 Rho, Italy
Interests: women mental health, mood disorders, perinatal, maternal functioning, psychopathology, gender

Special Issue Information

Dear Colleagues,

we are planning a Special Issue entitled “Gender differences in mood disorders during the lifespan: towards a precision medicine” in the International Journal of Environmental Research and Public Health: a peer-reviewed scientific journal on the interdisciplinary area of environmental health sciences and public health. For detailed information look at https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijerph.

In the last decade the interest on gender differences in medicine have catch more attention, both with regard to diagnosis and treatment. We know that women are more prone to develop a mental disorder during lifespan, being perinatal period one of the most susceptible. The aim of our issue is to spread the actual knowledge in the field of gender differences in mood disorders during lifespan, considering vulnerability to psychopathology linked to exogenous and endogenous factors. The identification of biomarkers could represent a modifiable risk factor providing the opportunity for improved treatment trajectories for women wellbeing, also in order to find a sex-specific psychopharmacology treatment when needed. This Special Issue is open to any idea related to gender impact on women mental health. I have listed some keywords suggesting ideas, new concepts/suggestions will be accepted.

Dr. Marta Serati
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Mood disorders
  • women mental health
  • gender differences
  • perinatal
  • psychopathology
  • biomarkers

Published Papers (1 paper)

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Research

Article
The Independent Role of Body Mass Index (BMI) and Severity of Depressive Symptoms on Biological Changes of Women Affected by Overweight/Obesity
Int. J. Environ. Res. Public Health 2021, 18(6), 2923; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18062923 - 12 Mar 2021
Cited by 2 | Viewed by 983
Abstract
Background: Both obesity and depression are medical conditions associated with severe disability and biological abnormalities. Our aim was to study associations between Body Mass Index (BMI), depression and biological changes in women affected by overweight or obesity. Methods: Depressive symptoms were [...] Read more.
Background: Both obesity and depression are medical conditions associated with severe disability and biological abnormalities. Our aim was to study associations between Body Mass Index (BMI), depression and biological changes in women affected by overweight or obesity. Methods: Depressive symptoms were evaluated by the Beck Depression Inventory II (BDI-II) questionnaire in 200 women affected by overweight/obesity (mean age of the sample 52.7 ± 12.9 years, BMI 33.8 ± 5.5 kg/m2). A blood sample was obtained for evaluation of biochemical (oxytocin and vitamin D), inflammatory and epigenetic (methylation of clock genes) parameters. Multivariable linear regression models were used to study the association between BMI or severity of depressive symptoms (BDI-II scores) with different biomarkers. Results: BMI was found to be associated with severity of depressive symptoms (p = 0.050). Severity of obesity resulted to be associated with lower plasma levels of oxytocin (p = 0.053), vitamin D deficiency (p = 0.006) and higher plasma levels of IFN-γ (p = 0.004), IL-6 (p = 0.013), IL-7 (p = 0.013), TNF-alpha (p = 0.036) and chemokine ligand 3 (CCL3) (p = 0.013, R2 = 0.03). Severity of depression was significantly associated with more methylation of clock genes CRY1 (p = 0.034, R2 = 0.16) and CRY2 (p = 0.019, R2 = 0.47). More severe depression together with higher levels of IL-8 strongly predicted lower methylation of CLOCK gene (p = 0.009); Conclusions: Different biological abnormalities have been found to be independently associated with BMI and severity of depressive symptoms in women affected by overweight/obesity. The complex interplay between overweight, depression and biological changes will have to be better clarified by future studies. Full article
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