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Gene-Environment Interaction in Chronic Diseases

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 484

Special Issue Editors

Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia (PV), Italy
Interests: respiratory diseases; neurological diseases; environmental exposure; occupational exposure; gene-environment interaction
Department of Public Health, Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, 27100 Pavia (PV), Italy
Interests: biostatistics; genetic epidemiology; clinical epidemiology; neurodegenerative diseases; global health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The pathogenesis of common diseases, especially chronic conditions, is a multifactorial process modulated by a complex interplay between genes and the environment. The burden of chronic diseases is rapidly increasing worldwide. The World Health Organization has estimated that, in 2020, chronic diseases will contribute approximately 57% of the global burden of disease. Chronic inflammatory and immune-mediated diseases, such as asthma, COPD, and diabetes are among the most common. This has led to concern about how the modern lifestyle and the environment may trigger innate physiologic defense mechanisms and, based on genetic predisposition, determine phenotype development.

Medical research is facing a significant challenge: improving the accuracy and precision in evaluating the role of environmental and genetic risk factors and their interaction. The awareness of the multifactorial nature of the phenotype development will greatly help in the early diagnosis, management, and prevention of chronic diseases, with important consequences on people and public health achievements. Molecular and genetic epidemiological studies provide tempting evidence suggesting that genes and the environment can interact to increase/decrease the risk for developing chronic disease. However, some limitations, such as the size of the populations required to examine gene–environment interactions, are still major obstacles to translating this knowledge into practical public health applications.

Current population studies are starting to incorporate experimental and analytical approaches that could provide more solid and comprehensive results; we should rely on those studies, and we should promote collaboration among investigators with different expertise to improve and strengthen the scientific evidence.

Therefore, papers addressing these topics are invited for this Special Issue, especially those with a practical focus on public health applications. New research papers, reviews, or papers dealing with new approaches to derive gene–environment interactions are welcome.

Dr. Simona Villani
Assoc. Prof. Dr. Maria Cristina Monti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic disease
  • inflammation
  • immunology
  • environment
  • genetic susceptibility
  • lifestyle
  • gene–environment interaction
  • genetic epidemiology
  • environmental epidemiology

Published Papers

There is no accepted submissions to this special issue at this moment.
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