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Challenges and Future Trends in Intensive Health Care

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 6909

Special Issue Editors

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, SeoulNational University College of Medicine, Seongnam 13620, Korea
Interests: sepsis; acute respiratory distress syndrome; intensive care units; shock; resuscitation; artificial intelli-gence
Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, SeoulNational University College of Medicine, Seongnam 13620, Korea
Interests: sepsis; acute respiratory distress syndrome; intensive care units; shock; resuscitation; artificial intelligence

Special Issue Information

Dear Colleagues,

Critical care medicine has seen continuous development in human history for a long duration. As a result, mortality and morbidity rates associated with various critical illnesses, including sepsis and acute respiratory distress syndrome, have been reducing. Currently, various studies are being conducted globally to improve the prognosis of critically ill patients. We would like to consider with research results that can be helpful in the diagnosis and treatment of various critical illnesses in this special issue. Even negative results in trials are welcome, and various types of research results, including meta-analysis and review papers, are also welcome. If you have any content that can be useful in the future development of critical care medicine utilizing artificial intelligence, machine learning, or computer science, please do submit it. In addition, research results related to precision medicine, which is recently attracting attention as a form of intensive care medicine of the future (Zimmerman 2019), are welcome.

Dr. In-Ae Song
Dr. Tak Kyu Oh
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ARDS
  • sepsis
  • septic shock
  • ICU
  • critical care
  • shock
  • resuscitation
  • precision medicine
  • artificial intelligence
  • data science
  • survivor
  • mortality

Published Papers (3 papers)

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Research

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13 pages, 992 KiB  
Article
Role of SatO2, PaO2/FiO2 Ratio and PaO2 to Predict Adverse Outcome in COVID-19: A Retrospective, Cohort Study
by Stefano Sartini, Laura Massobrio, Ombretta Cutuli, Paola Campodonico, Cristina Bernini, Marina Sartini, Maria Luisa Cristina, Luca Castellani, Ludovica Ceschi, Marzia Spadaro, Angelo Gratarola and Paolo Barbera
Int. J. Environ. Res. Public Health 2021, 18(21), 11534; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph182111534 - 02 Nov 2021
Cited by 15 | Viewed by 3372
Abstract
COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive [...] Read more.
COVID-19 respiratory failure is a life-threatening condition. Oxygenation targets were evaluated in a non-ICU setting. In this retrospective, observational study, we enrolled all patients admitted to the University Hospital of Genoa, Italy, between 1 February and 31 May 2020 with an RT-PCR positive for SARS-CoV-2. PaO2, PaO2/FiO2 and SatO2% were collected and analyzed at time 0 and in case of admission, patients who required or not C-PAP (groups A and B) were categorized. Each measurement was correlated to adverse outcome. A total of 483 patients were enrolled, and 369 were admitted to hospital. Of these, 153 required C-PAP and 266 had an adverse outcome. Patients with PaO2 <60 and >100 had a higher rate of adverse outcome at time 0, in groups A and B (OR 2.52, 3.45, 2.01, respectively). About the PaO2/FiO2 ratio, the OR for < 300 was 3.10 at time 0, 4.01 in group A and 4.79 in group B. Similar odds were found for < 200 in any groups and < 100 except for group B (OR 11.57). SatO2 < 94% showed OR 1.34, 3.52 and 19.12 at time 0, in groups A and B, respectively. PaO2 < 60 and >100, SatO2 < 94% and PaO2/FiO2 ratio < 300 showed at least two- to three-fold correlation to adverse outcome. This may provide simple but clear targets for clinicians facing COVID-19 respiratory failure in a non ICU-setting. Full article
(This article belongs to the Special Issue Challenges and Future Trends in Intensive Health Care)
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13 pages, 483 KiB  
Article
Prior Antiplatelet Therapy and Stroke Risk in Critically Ill Patients Undergoing Extracorporeal Membrane Oxygenation
by Tak-Kyu Oh, In-Ae Song, Sol-Yi Lee and Hey-Ran Choi
Int. J. Environ. Res. Public Health 2021, 18(16), 8679; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18168679 - 17 Aug 2021
Cited by 1 | Viewed by 1449
Abstract
We aimed to investigate whether prior exposure to antiplatelet therapy (anti-PLT) was associated with stroke incidence after the initiation of extracorporeal membrane oxygenation (ECMO) therapy. We conducted a population-based cohort study based on health records obtained from the National Health Insurance Service database [...] Read more.
We aimed to investigate whether prior exposure to antiplatelet therapy (anti-PLT) was associated with stroke incidence after the initiation of extracorporeal membrane oxygenation (ECMO) therapy. We conducted a population-based cohort study based on health records obtained from the National Health Insurance Service database in South Korea. Adult patients (aged ≥ 18 years) who underwent ECMO therapy in the intensive care unit during 2009–2018 were enrolled. In total, 17,237 patients who underwent ECMO therapy were included; stroke occurred in 779 (4.5%) of 17,237 patients within 7 days of initiating the ECMO therapy. The number of patients in the anti-PLT and control groups was 3909 (22.7%) and 13,328 (77.3%), respectively. In the multivariable logistic regression analysis, the anti-PLT group showed 33% lower incidence of stroke than the control group (odds ratio (OR): 0.67, 95% confidence interval (CI): 0.55–0.82; p < 0.001). The cardiovascular group showed 35% lower incidence of stroke than the control group (OR: 0.65, 95% CI: 0.52–0.78; p < 0.001), whereas the respiratory group (p = 0.821) and the other group (p = 0.705) did not show any significant association. Prior anti-PLT therapy was associated with a lower incidence of stroke within 7 days of initiating ECMO therapy, which was more evident in the cardiovascular group. Full article
(This article belongs to the Special Issue Challenges and Future Trends in Intensive Health Care)
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9 pages, 4027 KiB  
Case Report
A Successful Outcome of Veno-Venous Extracorporeal Membrane Oxygenation in Obese Patients with Respiratory Failure in the Course of COVID-19: A Report of Two Cases
by Jarosław Janc, Lidia Łysenko, Olga Lewandowska, Olimpia Chrzan, Michał Suchański, Marek Gemel and Patrycja Leśnik
Int. J. Environ. Res. Public Health 2022, 19(5), 2761; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19052761 - 27 Feb 2022
Cited by 1 | Viewed by 1443
Abstract
The use of extracorporeal membrane oxygenation (ECMO) in patients with respiratory failure in the course of COVID-19 indicates its limited efficacy and high mortality rates. It seems that one of the conditions for the success of veno-venous ECMO (VV ECMO) in obese patients [...] Read more.
The use of extracorporeal membrane oxygenation (ECMO) in patients with respiratory failure in the course of COVID-19 indicates its limited efficacy and high mortality rates. It seems that one of the conditions for the success of veno-venous ECMO (VV ECMO) in obese patients with COVID-19 is the correct qualification and rapid implementation of this method. We present two cases of obese patients with acute respiratory distress syndrome (ARDS) as a result of SARS-CoV-2 infection with the successful use of ECMO. Two 41-year-old obese patients (Case 1: BMI 31.5 kg/m2 and Case 2: 44.5 kg/m2), with pneumonia and severe respiratory failure in the course of COVID-19, underwent ECMO therapy. The Extracorporeal Life Support Organization (ELSO) guidelines were used to qualify the patients. Due to the persistence of PaO2/FiO2 rate <80 for 6 h, a decision was made to implement VV ECMO. Both patients were discharged from the intensive care unit (Case 1: on day 35; Case 2: on day 22). Rapid implementation of VV ECMO in middle-aged, obese patients with ARDS in the course of COVID-19 showed a positive outcome. Full article
(This article belongs to the Special Issue Challenges and Future Trends in Intensive Health Care)
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