Special Issue "Advances in Macrophage Biology and Their Role in Development and Disease"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".
Deadline for manuscript submissions: 31 December 2021.
Interests: macrophage biology; immune mediated wound healing; biophysical regulation of macrophages; inflammation and NF-kB signaling; immunomodulation and mechanotransduction
Interests: inflammation; NF-kB signaling; preimplantation embryo development and differentiation; mitochondrial morphogenesis
Macrophages are innate immune cells that are found in all tissues and exhibit great functional diversity. These professional phagocytes sense the tissue damage, and recognize and clear invading pathogens, apoptotic cells, and debris. Apart from these immunological and tissue repair functions, macrophages are also involved in the development of various tissues and maintaining metabolic homeostasis. Upon tissue damage following injury or infection, recruited monocytes are differentiated to macrophages and acquire a pro-inflammatory phenotype. Although inflammatory macrophages are essential to help clear the invading organisms, they can lead to disease progression if not quickly controlled. This scenario is dominant in many chronic inflammatory and autoimmune diseases, including cancer, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, and fibrosis. Further, the biophysical and biochemical cues in the microenvironment can steer macrophages towards pro-inflammatory or pro-healing phenotypes. Therefore, investigating and understanding the molecular mechanisms of macrophage plasticity is essential to exploit its therapeutic potential.
Dr. Vijaykumar S. Meli
Dr. Shubhendu Sen Roy
Dr. Arnab Chattopadhyay
Manuscript Submission Information
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Macrophage and Cardiovascular health
Tissue repair and homeostasis