Special Issue "Advances in Macrophage Biology and Their Role in Development and Disease"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Vijaykumar S. Meli
E-Mail Website
Guest Editor
Department of Biomedical Engineering, University of California Irvine, Irvine 92697, USA
Interests: macrophage biology; immune mediated wound healing; biophysical regulation of macrophages; inflammation and NF-kB signaling; immunomodulation and mechanotransduction
Dr. Shubhendu Sen Roy
E-Mail Website
Assistant Guest Editor
(Present) FUJIFILM Irvine sceintific, Irvine. (Former) Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Interests: inflammation; NF-kB signaling; preimplantation embryo development and differentiation; mitochondrial morphogenesis
Dr. Arnab Chattopadhyay
E-Mail Website
Assistant Guest Editor
Department of Medicine, University of California Los Angeles (UCLA), Los Angeles, 90095, USA
Interests: lipid biology; cardiology; inflammation and immune cells

Special Issue Information

Dear Colleagues,

Macrophages are innate immune cells that are found in all tissues and exhibit great functional diversity. These professional phagocytes sense the tissue damage, and recognize and clear invading pathogens, apoptotic cells, and debris. Apart from these immunological and tissue repair functions, macrophages are also involved in the development of various tissues and maintaining metabolic homeostasis. Upon tissue damage following injury or infection, recruited monocytes are differentiated to macrophages and acquire a pro-inflammatory phenotype. Although inflammatory macrophages are essential to help clear the invading organisms, they can lead to disease progression if not quickly controlled. This scenario is dominant in many chronic inflammatory and autoimmune diseases, including cancer, atherosclerosis, rheumatoid arthritis, inflammatory bowel disease, and fibrosis. Further, the biophysical and biochemical cues in the microenvironment can steer macrophages towards pro-inflammatory or pro-healing phenotypes. Therefore, investigating and understanding the molecular mechanisms of macrophage plasticity is essential to exploit its therapeutic potential.

Dr. Vijaykumar S. Meli
Dr. Shubhendu Sen Roy
Dr. Arnab Chattopadhyay
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Macrophage biology

Chronic inflammation

Macrophage and Cardiovascular health


Tissue repair and homeostasis

Published Papers

This special issue is now open for submission.
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