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Multiple Environmental Exposures and Cardiorespiratory Diseases

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 8658

Special Issue Editors


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Guest Editor
Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Interests: respiratory diseases; environmental medicine; air pollution; inflammatory and immune responses; environmental exposures

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Guest Editor
North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA
Interests: metals; cardiovascular epidemiology; multiple environmental exposures; Metals and their effects on environmental and human health; mixed exposures, environmental epidemiology; environmental and urban geochemistry; and global health

Special Issue Information

Cardiovascular and respiratory diseases are among the leading causes of mortality worldwide. The effects of multiple environmental exposures (biological, chemical, physical, and psychosocial) all play a significant role in initiating and promoting disease and pathology. These exposures usually occur together, accrue over the life course, and affect various at-risk populations differentially. Unfortunately, little work has been done in this vital area of inquiry and represents a critical topic which requires more research, newer methods, and better approaches from multiple research disciplines to better understand who, when, where, and why exposure occurs and the impact of the exposure on cardiovascular and respiratory health. This Special Issue aims to explore the most recent research findings on multiple and mixed exposures to elucidate the role of traditional and emerging contaminants on the cardiovascular and respiratory system. Clinical, preclinical, and translational studies are welcome, as well as in-depth reviews that critically synthesize relevant published studies. 

We are excited about this opportunity to create this Special Issue to give a platform to the dynamic efforts happening around the world to explore and characterize the role these exposures play on cardiorespiratory health. We look forward to hearing from you and other potential contributors from around the world.

Dr. Neil Alexis
Dr. Emmanuel Obeng-Gyasi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • respiratory diseases
  • cardiopulmonary diseases
  • mixed exposures
  • cumulative exposures
  • multiple exposures

Published Papers (3 papers)

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Research

10 pages, 348 KiB  
Article
Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study
by Geraldo A. Maranhao Neto, Anna Bartoskova Polcrova, Anna Pospisilova, Ludek Blaha, Jana Klanova, Martin Bobak and Juan P. Gonzalez-Rivas
Int. J. Environ. Res. Public Health 2022, 19(21), 13898; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph192113898 - 26 Oct 2022
Cited by 3 | Viewed by 1516
Abstract
Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the [...] Read more.
Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25–89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p < 0.05) associations between the ln-transformed PFOA and glucose (β = 0.01), systolic (β = 0.76) and diastolic blood pressure (β = 0.65); total cholesterol (β = 0.07) and LDL-c (β = 0.04); and PFOS with glucose (β = 0.03), BMI (β = 2.26), waist circumference (β = 7.89), systolic blood pressure (β = 1.18), total cholesterol (β = 0.13), and HDL-c (β = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature. Full article
(This article belongs to the Special Issue Multiple Environmental Exposures and Cardiorespiratory Diseases)
9 pages, 343 KiB  
Article
Combined Effect of Lead Exposure and Allostatic Load on Cardiovascular Disease Mortality—A Preliminary Study
by Emmanuel Obeng-Gyasi, Alesia C. Ferguson, Katherine A. Stamatakis and Michael A. Province
Int. J. Environ. Res. Public Health 2021, 18(13), 6879; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18136879 - 26 Jun 2021
Cited by 20 | Viewed by 3052
Abstract
This study explores the combined effect of lead (Pb) exposure and an index of chronic physiological stress on cardiovascular disease mortality using data from the National Health and Nutrition Examination Survey (NHANES) 1999–2008 linked to 1999–2014 National Death Index data. Chronic physiological stress [...] Read more.
This study explores the combined effect of lead (Pb) exposure and an index of chronic physiological stress on cardiovascular disease mortality using data from the National Health and Nutrition Examination Survey (NHANES) 1999–2008 linked to 1999–2014 National Death Index data. Chronic physiological stress was measured using the allostatic load (AL) index, which was formed by analyzing markers from the cardiovascular, inflammatory, and metabolic systems, with Pb levels, assessed using blood lead levels (BLL). The dataset was analyzed with statistical techniques to explore (a) the relationship between Pb exposure and AL, and (b) the combined role of Pb and AL on cardiovascular disease mortality. Results indicated that AL was more elevated in those with BLLs above the 50th percentile in the US population and that those with elevated AL were more likely to have high BLL. Finally, the interaction of AL and BLL significantly increased the likelihood of cardiovascular disease mortality. These findings highlight the need for considering the totality of exposures experienced by populations to build holistic programs to prevent Pb exposure and reduce stressors to promote optimal health outcomes and reduce cardiovascular mortality risk. Full article
(This article belongs to the Special Issue Multiple Environmental Exposures and Cardiorespiratory Diseases)
12 pages, 1446 KiB  
Article
Health Impact Assessment of Artisanal and Small-Scale Gold Mining Area in Myanmar, Mandalay Region: Preliminary Research
by Win Thiri Kyaw, Xiaoxu Kuang and Masayuki Sakakibara
Int. J. Environ. Res. Public Health 2020, 17(18), 6757; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17186757 - 16 Sep 2020
Cited by 9 | Viewed by 3228
Abstract
Increasing artisanal and small-scale gold mining (ASGM) in developing countries has raised health concerns in mining communities. A preliminary health survey was conducted in Thabeikkyin Township, Mandalay Region, Myanmar, in February 2020 to assess the health conditions of an ASGM community. Respiratory function [...] Read more.
Increasing artisanal and small-scale gold mining (ASGM) in developing countries has raised health concerns in mining communities. A preliminary health survey was conducted in Thabeikkyin Township, Mandalay Region, Myanmar, in February 2020 to assess the health conditions of an ASGM community. Respiratory function and other clinical assessments were evaluated in miners and non-miners, and participants’ hair was analyzed for heavy metals. Respiratory function of miners was similar to that of non-miners. However, miners’ respiratory function declined with longer mining activity duration. In total, 3 out of 18 miners showed neurological signs and symptoms of chronic mercury intoxication. The median concentration of the hair mercury was significantly higher in miners than non-miners (P = 0.01), and 9 out of 18 miners and 2 out of 11 non-miners showed the warning level of mercury. We found that, despite an association between declining respiratory function and length of time mining, only a minority of miners showed clinical features of chronic mercury intoxication. Further clinical surveys with a larger sample size are necessary to determine the broader health status of this community. In addition, clinical indicators such as pulmonary function tests are recommended as additional criteria for the diagnosis of mercury intoxication. Full article
(This article belongs to the Special Issue Multiple Environmental Exposures and Cardiorespiratory Diseases)
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