Dear Colleagues,

Humans are exposed to, or take in, food, water, air, and other environmental agents on a daily basis. At the same time, humans release non-natural substances into the environment, including personal care products, and prescription and illicit drugs. The combination of these exposures can exert profound effects on human and environmental health. This issue explores the contact of humans or other organisms with chemical, physical, and biologic stressors and their fate in living systems. Through Exposure Science and modern Toxicology, we aim to highlight how advanced ‘Omics’ approaches can help us to understand stressors that affect human and ecosystem health and interfaces, with sensor systems, analytical methods, molecular biology, computational tools, and bioinformatics. In particular, we aim to highlight how these multi-faceted approaches inform  advances in new preventative and therapeutic strategies for chronic diseases. Some of the key knowledge gaps in this area are:

• The health implications of various routes and levels of exposure, including chronic, low dose exposure
• Development of new technologies and/or approaches (e.g. bioinformatics, ‘Omics’, etc.) to detect endogenous or exogenous toxins which may assist in diagnostic monitoring and surveillance efforts, or inform decisions to protect human health
• ‘Omics’-driven mechanistic studies of toxicity in various organ systems with a focus on developing potential therapeutic strategies
• Monitoring and modeling toxin bioaccumulation in food chains and food webs
• Exploiting novel metabolic and degradation pathways of toxins for potential clinical benefit
• Epidemiology and population health measures, including the surveillance and identification of clusters
• Public health policy efforts, including community level intervention and prevention strategies

Using the principles of exposure science, epidemiology and modern toxicology, we endeavor to demonstrate how state-of-the-art ‘Omics’ approaches can help us to understand how various toxins affect human and ecosystem health, with an aim to prevent or treat their harmful effects.

Dr. Steven T. Haller
Dr. David J. Kennedy
Guest Editors

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• toxicology
• emergent chemicals of concern
• environmental toxins
• human health
• exposure science
• sensors
• ‘Omics’
• epidemiology
• therapeutics
• prevention