Special Issue "Pathogenesis and Prevention of Substance-Use Disorders and Metabolic Syndrome"

Special Issue Editor

Dr. Anika Toorie
E-Mail Website
Guest Editor
Rhode Island College, 600 Mount Pleasant Avenue, Providence, RI 02908, USA
Interests: neuroendocrinology; metabolism; stress; diabetes; opioids; substance-abuse; obesity; transgenerational; addiction

Special Issue Information

Dear Colleagues,

Substance use disorders (i.e., opioid or alcohol dependency) and metabolic syndrome are distinct global public health issues that continue to prevail due to increased access to drugs of abuse, and palatable hypercaloric diets, respectively. The brain’s homeostatic centers and reward systems are involved in aspects of both substance addiction and energy homeostasis. Beyond defects in these central mechanisms, aberrations to peripheral (i.e., endocrine) systems also mediate the pathophysiology of substance use disorder, as well as clinical features of metabolic syndrome (i.e., obesity, insulin resistance). Thus, understanding common and unique mechanisms underlying the development of these diseases will provide groundwork for the development or refinement of pharmacologics with broad applications that can be further tailored for targeted diseases.

This Special Issue seeks research papers that provide insight with regard to the interplay between common and unique systems that influence vulnerability to substances of abuse and/or metabolic dysfunction. We are particularly interested in articles that report on sex-specific effects. Further, we seek original reports describing mechanisms involved in the intergenerational transmission of risk factors related to substance use disorder and/or metabolic syndrome. We encourage the submission of original basic-science, translational, and clinical-based papers produced from interdisciplinary collaborations, systematic reviews, and meta-analysis.

Dr. Anika Toorie
Guest Editor

Manuscript Submission Information

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  • Metabolic syndrome
  • Substance abuse disorder
  • Obesity
  • Diabetes
  • Epigenetics
  • Neuroendocrine axes
  • Addiction

Published Papers (1 paper)

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Changes in Drug Use Patterns during the COVID-19 Pandemic in Italy: Monitoring a Vulnerable Group by Hair Analysis
Int. J. Environ. Res. Public Health 2021, 18(4), 1967; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18041967 - 18 Feb 2021
Cited by 5 | Viewed by 1160
From 22 March until 18 May 2020, a complete lockdown in Italy was ordered as a countermeasure against the COVID-19 pandemic. Social isolation measures affect some populations more than others, and people with drug and/or alcohol disorders (SUDs) are more likely to be [...] Read more.
From 22 March until 18 May 2020, a complete lockdown in Italy was ordered as a countermeasure against the COVID-19 pandemic. Social isolation measures affect some populations more than others, and people with drug and/or alcohol disorders (SUDs) are more likely to be adversely affected. This study presents, for the first time, laboratory data on the use of alcohol and drugs in a high-risk population during Italy’s first wave of the COVID-19 pandemic. Thirty subjects with SUDs were monitored for the use of illicit drugs and alcohol every 3 months before, during and after the lockdown, by hair analysis. The number of samples positive for heroin, cocaine, MDMA and cannabis fell considerably during the lockdown and then resumed to pre-lockdown levels when the period of confinement was over. Interestingly, the consumption of benzodiazepines and alcohol followed the opposite trend; both the number of benzodiazepine-positive samples and the level of alcohol consumption increased and remained high, even at the end of the lockdown. The confinement measures produced significant changes in drug/alcohol use patterns, with a shift toward the use of substances that were more easily accessible, used as self-medication for negative feelings, and used to alleviate the effects of abstinence from drugs that were no longer readily available. Full article
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