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Special Issue "Reproductive Therapy and Perinatal Outcome"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Women's Health".

Deadline for manuscript submissions: closed (1 December 2020).

Special Issue Editor

Dr. Hiroaki Tanaka
E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan
Interests: obstetrics; fetal growth restriction; obstetrical hemorrhage; maternal mortality; pregnancy with complications

Special Issue Information

Dear Colleagues,

Assisted reproductive technology (ART) has advanced significantly in recent years, and the incidence of pregnancy by ART has increased. Currently in Japan, 1 in 18 women give birth because of ART. The number of babies born by ART is also predicted to increase in the future. Therefore, perinatal outcomes for pregnancy by ART need to be understood. Currently, pregnancies by ART are known to be associated with a high rate of premature birth, low-birth-weight infants, fetal malposition, an abnormal placenta and umbilical cord, a high rate of cesarean section, perinatal mortality, and a high amount of blood loss during delivery. However, perinatal outcomes for pregnancy by ART are not yet understood in their entirety. Therefore, the Special Issue “Reproductive Therapy and Perinatal Outcome” has been planned.

This Special Issue seeks research papers on various aspects of women’s reproductive health, such as assisted reproductive technology, gynecological diseases, and perinatal outcomes. We also welcome original research papers based on interdisciplinary work and multi-country collaborative research.


Dr. Hiroaki Tanaka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Perinatal outcome
  • Reproductive therapy
  • Assisted reproductive technology
  • Pregnancy
  • Placental previa
  • Preterm birth
  • Endometriosis
  • Adenomyosis

Published Papers (1 paper)

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First Trimester Uterine Rupture: A Case Report and Literature Review
Int. J. Environ. Res. Public Health 2020, 17(8), 2976; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17082976 - 24 Apr 2020
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The aim is to report a case of spontaneous uterine rupture in the first trimester of pregnancy and to review the literature on the topic. Methods: A literature search was performed using PubMed and Scopus. Relevant English articles were identified without any time [...] Read more.
The aim is to report a case of spontaneous uterine rupture in the first trimester of pregnancy and to review the literature on the topic. Methods: A literature search was performed using PubMed and Scopus. Relevant English articles were identified without any time or study limitations. The data were aggregated, and a summary statistic was calculated. Results: A 35-year-old gravida 5, para 2 was admitted at our department because of fainting and abdominal pain. The woman had a first-trimester twin pregnancy and a history of two previous cesarean sections (CSs). Suspecting a uterine rupture, an emergency laparotomy was performed. The two sacs were completely removed, and the uterine rupture site was closed with a double-layer suture. The patient was discharged from hospital four days later in good condition. On the basis of this experience, a total of 76 case reports were extracted from PubMed and included in the review. Fifty-three patients out of 76 (69.74%) underwent previous surgery on the uterus. Most women (67.92%) had a CS, and in this group a cesarean scar pregnancy (CSP) or a placenta accreta spectrum (PAS) disorder was found to be the etiology in 77.78% of cases. Furthermore, 35.85% of the women had hysterectomy after uterine rupture. Twenty-three patients out of 76 (30.26%) had an unscarred uterus. Of this group, most women presented a uterine anomaly (43.48%). Moreover, 17.39% of these women had a hysterectomy. Conclusion: According to the literature, the current pandemic use of CS explains most cases of first-trimester uterine rupture. Full article
(This article belongs to the Special Issue Reproductive Therapy and Perinatal Outcome)
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