Special Issue "Risk Factors, Prevention and Management of Cardiometabolic Diseases: Infection and Chronic Inflammatory Perspectives"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Dr. Mohammad Radwanur Talukder
E-Mail Website
Guest Editor
Baker Heart and Diabetes Institute, Alice Springs Hospital, Alice Springs 0870, Northern Territory, Australia
Interests: infectious disease; inflammation; chronic disease; indigenous health; climate change and health impacts
Dr. Abu Mohammed Naser Titu
E-Mail Website
Assistant Guest Editor
Hubert Department of Global Health, Emory Global Diabetes Research Center, Emory University, Atlanta, GA 30322, USA
Interests: environmental exposures and cardiometabolic diseases; cardiovascular epidemiology; planetary health; drinking water quality and cardiometabolic health
Dr. Mohd Anisul Karim
E-Mail Website
Assistant Guest Editor
1) Centre for Therapeutic Target Validation, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; 2) Nuffield Department of Population Health, University of Oxford, Oxford OX1 2JD, UK
Interests: inflammation; genetics; mendelian randomization; drug repositioning

Special Issue Information

Dear Colleagues,

In recent decades, chronic inflammation has emerged as a potentially modifiable risk factor for cardiometabolic diseases. While physiological levels of inflammatory activity represent an important biological mechanism to combat infections and repair damaged tissues, excessive inflammatory activities can damage physiological systems beyond repair. Furthermore, the low-grade inflammatory milieu from (recurrent) infections can potentially contribute to the development of cardiometabolic diseases or exacerbate existing conditions.

This Special Issue focuses on research demonstrating the nexus between infection, lifestyle, environmental exposures, chronic inflammation, and cardiometabolic diseases from a global public health perspective. Potential research topics may include (but are not limited to) reviewing the current state of the nexus and exploring epidemiological factors and public health management approaches to mitigate the impact of inflammation and cardiometabolic diseases on each other. We also encourage research that helps to understand the contribution of emerging and re-emerging infections to susceptibility or severity of cardiometabolic diseases, and research that illustrates the health system challenges in developed and developing countries.

In this Special Issue, we invite researchers in clinical practice, public health, epidemiology, health economics, immunology, and other social sciences to submit high-quality original research or systematic reviews related to the issues in this research area.

Dr. Mohammad Radwanur Talukder
Dr. Abu Mohammed Naser Titu
Dr. Mohd Anisul Karim
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cardiometabolic disease
  • Epidemiology
  • Risk factors
  • Chronic inflammation
  • Environmental exposure
  • Infection
  • Public health

Published Papers (1 paper)

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Betel-Quid Chewing, Heart Failure, and Premature Ventricular Contractions in Patients with Cardiopulmonary Symptoms
Int. J. Environ. Res. Public Health 2020, 17(20), 7472; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph17207472 - 14 Oct 2020
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Betel-quid (BQ) is a commonly used psychoactive substance that renders a specific cardiotoxicity. The purpose of this study was to investigate the association between BQ chewing and premature ventricular contractions (PVC) in patients with cardiopulmonary symptoms, and examine the potential influences of cardiovascular [...] Read more.
Betel-quid (BQ) is a commonly used psychoactive substance that renders a specific cardiotoxicity. The purpose of this study was to investigate the association between BQ chewing and premature ventricular contractions (PVC) in patients with cardiopulmonary symptoms, and examine the potential influences of cardiovascular and chronic diseases on such relationship. Participants were 146 patients with cardiopulmonary symptoms who participated in 24-h Holter electrocardiogram monitoring during 2012–2018 in a hospital serving residents that lived in a BQ high prevalence area. Data on substance uses and medical histories for cardiovascular and chronic diseases were collected. Baron–Kenny method was employed to evaluate possible mediation. In patients with cardiopulmonary symptoms, 36.3% were BQ users and 63.7% were nonusers. Adjusting for covariates, BQ chewing was significantly associated with heart failure and diabetes mellitus (adjusted odds ratio (aOR) = 3.4 and 2.3, respectively), but only heart failure was significantly correlated with a low and high level of PVC. Additionally controlling for the effect of heart failure, the risk of high PVC for BQ users reduced from 3.60 to 2.88; however, the risk for BQ chewers remained significant (95% CI: 1.06–7.84). Heart failure was found to explain 27.7% of the excessive effect of BQ use on high PVC. In conclusion, BQ use is directly associated with an elevated risk of high PVC in patients with cardiopulmonary symptoms. The higher risk might be elevated among patients who suffered heart failure. Given several research limitations, the findings from this study offer future opportunities for validation. Full article
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