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Impact of the Circadian Rhythm in Health and Diseases

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 4165

Special Issue Editor

Faculty of Medicine, Graduate School of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa Prefecture 761-0793, Japan
Interests: salt and cancer; metabolic syndrome; development of chronotherapeutics; breast cancer metastasis; circadian clock

Special Issue Information

Dear colleagues,

Environmental cues are strongly linked to the modification of biological processes in almost all organisms, ranging from prokaryotes to eukaryotes and including humans. The circadian timing system plays an important role in this process by synchronizing the internal biology of an organism with that of the external environment in a 24 hour daily rhythmic cycle. In mammals, including humans, circadian rhythms are regulated by internal oscillators at the transcriptional levels in nearly all cells and tissues and thereby control 24 hour physiological and behavioral processes. Maintaining the circadian rhythms is critical to human health and survival. However, in the current ‘24/7’ lifestyle, the individual behavioral cycle greatly impacts on the endogenous oscillators as well as on biological rhythms. Alterations in circadian rhythm have been associated with several significant health problems, including metabolic syndrome, cardiovascular diseases, inflammatory diseases, and even cancer, indicating the strong link between the circadian system and overall health. The last decade of chronobiological research has pointed out the critical role of alterations of the circadian timing system in the development of several pathological conditions. Recently, therapeutic strategies based on chronobiology, involving either the timing of drug administration or the use of novel pharmacological compounds that modify the circadian clock and the biological rhythm, have become popular in clinical practice due to their observed meaningful outcomes.

This Special Issue, "Impact of Circadian Rhythm in Health and Diseases", will cover a range of topics in the field of chronobiology, emphasizing the novel concept of circadian rhythm in health and diseases and chronotherapies targeting the modulation of the circadian timing system. This Special Issue will focus on both basic studies and translational research in order to provide an in-depth representation of the contribution of the circadian rhythm to health and diseases. Original articles, up-to-date review articles, and commentaries are all welcome.

Dr. Rahman Md Asadur
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • circadian rhythm
  • circadian clock
  • clock genes
  • circadian disruption
  • chronotherap
  • environmental disturbances

Published Papers (1 paper)

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Review

15 pages, 1906 KiB  
Review
Renoprotective Effects of Mangiferin: Pharmacological Advances and Future Perspectives
by Sumaya Akter, Akhi Moni, Golam Mahbub Faisal, Muhammad Ramiz Uddin, Nourin Jahan, Md Abdul Hannan, Asadur Rahman and Md Jamal Uddin
Int. J. Environ. Res. Public Health 2022, 19(3), 1864; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19031864 - 07 Feb 2022
Cited by 12 | Viewed by 3387
Abstract
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have [...] Read more.
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have protective effects against various renal pathologies could be potential drug candidates for kidney diseases. Mangiferin is a natural polyphenol predominantly isolated from Mangifera indica and possesses multiple health benefits against various human ailments, including kidney disease. The main objective of this review is to update the renoprotective potentials of mangiferin with underlying molecular pharmacology and to highlight the recent development of mangiferin-based therapeutics toward kidney problems. Literature published over the past decade suggests that treatment with mangiferin attenuates renal inflammation and oxidative stress, improves interstitial fibrosis and renal dysfunction, and ameliorates structural alteration in the kidney. Therefore, mangiferin could be used as a multi-target therapeutic candidate to treat renal diseases. Although mangiferin-loaded nanoparticles have shown therapeutic promise against various human diseases, there is limited information on the targeted delivery of mangiferin in the kidney. Further research is required to gain insight into the molecular pharmacology of mangiferin targeting kidney diseases and translate the preclinical results into clinical use. Full article
(This article belongs to the Special Issue Impact of the Circadian Rhythm in Health and Diseases)
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