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Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome
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Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 7679

Special Issue Editors

Prof. Dr. Jin Hee Kim

E-Mail Website
Guest Editor
Department of Integrative Bioscience & Biotechnology, Sejong University, Seoul 05006, Republic of Korea
Interests: complex diseases; susceptible population; elderly; hypertension; diabetes; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Kyoung-Nam Kim

E-Mail Website
Guest Editor
Public Healthcare Center, Seoul National University Hospital, Seoul 03080, Korea
Interests: environmental epidemiology
Prof. Dr. Seungho Lee

E-Mail Website
Guest Editor
Department of Preventive Medicine, College of Medicine, Dong-A University, Busan 49201, Korea
Interests: environmental epidemiology; risk assessment; pharmacokinetic modeling; biomonitoring
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Metabolic disorders such as diabetes are consistently increasing worldwide. Although there is a great deal of evidence for metabolic disorders, it is were limited because the development of metabolic disorders can be affected by a variety of factors, and they appear with complication. In addition, metabolic disorders have been found to be related with other complex diseases such as hypertension. This kind of complexity can lead to difficulties in interpreting conditions in relation with metabolic disorders.

A variety of chemicals are being developed, and several environmental chemicals have been known to affect the development of metabolic disorders including diabetes. These environmental chemicals could be ubiquitously and chronically exposed to the human body, and thus could be toxic in humans, particularly in vulnerable populations, even at low exposure doses. Although a variety of evidence supports the associations between several chemical exposures and metabolic disorders, limited evidence is available, particularly in vulnerable populations and particularly for their pathways.

This Special Issue seeks research papers on various aspects of potential risk factors, including environmental factors, complications, relations with other diseases, treatment, and mechanisms in relation with metabolic disorders. We especially encourage the submission of interdisciplinary works and multi-country collaborative research. We also encourage the submission of health-policy-related manuscripts that focus on issues related to the prevention and management of metabolic disorders. We welcome original research papers using different study designs as well as systematic reviews and meta-analyses.

Prof. Dr. Jin Lee Kim
Dr. Kyoung-Nam Kim
Prof. Dr. Seungho Lee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • metabolic disorders
  • complications
  • treatments
  • epidemiology
  • susceptible population
  • mechanism
  • prevention
  • management

Published Papers (4 papers)

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Research

10 pages, 844 KiB  
Article
Association between Blood Glucose Control and Subjective Cognitive Decline in Korean Patients with Diabetes Aged over 50 Years
by Dae-Hyung Koh, Yu-Jin Rho, Soon Young Lee, Kyoung-Nam Kim and Yeong Jun Ju
Int. J. Environ. Res. Public Health 2022, 19(12), 7267; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19127267 - 14 Jun 2022
Cited by 3 | Viewed by 1457
Abstract
This study aimed to investigate the association between blood glucose control and subjective cognitive decline in adult patients with diabetes. Using the 2018 data from the community health survey, we included 18,789 patients with diabetes aged ≥50 years who had complete responses recorded. [...] Read more.
This study aimed to investigate the association between blood glucose control and subjective cognitive decline in adult patients with diabetes. Using the 2018 data from the community health survey, we included 18,789 patients with diabetes aged ≥50 years who had complete responses recorded. Blood glucose control was the independent variable, and subjective cognitive decline was the dependent variable. Multivariable logistic regression analysis was used to analyze the association between blood glucose control and subjective cognitive decline. Multivariable logistic regression analysis showed that blood glucose control was inversely associated with subjective cognitive decline in patients with diabetes. Patients with uncontrolled blood glucose levels had higher odds of subjective cognitive decline than those with controlled blood glucose levels (odds ratio = 1.22; 95% confidence interval: 1.10, 1.34). Our findings suggest that patients with diabetes may demonstrate subjective cognitive decline if their blood glucose levels are not well-controlled. Full article
(This article belongs to the Special Issue Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome)
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13 pages, 710 KiB  
Article
Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the Relationship between Particulate Matter Exposure and Fasting Glucose Level
by Jin Hee Kim, Seungho Lee and Yun-Chul Hong
Int. J. Environ. Res. Public Health 2022, 19(10), 6241; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19106241 - 20 May 2022
Cited by 2 | Viewed by 1426
Abstract
Particulate matter (PM) has been linked to adverse health outcomes, including insulin resistance (IR). To evaluate the relationships between exposures to PM10, PM2.5–10, and PM2.5; the serum level of fasting glucose, a key IR indicator; and effects [...] Read more.
Particulate matter (PM) has been linked to adverse health outcomes, including insulin resistance (IR). To evaluate the relationships between exposures to PM10, PM2.5–10, and PM2.5; the serum level of fasting glucose, a key IR indicator; and effects of polymorphisms of two repair genes (PARP4 and ERCC1) on these relations, PMs exposure data and blood samples for glucose measurement and genotyping were collected from 527 Korean elders. Daily average levels of PMs during 8 days, from 7 days before examination to the health examination day (from lag day 7 to lag day 0), were used for association analyses, and mean concentrations of PM10, PM2.5–10, and PM2.5 during the study period were 43.4 µg/m3, 19.9 µg/m3, and 23.6 µg/m3, respectively. All three PMs on lag day 4 (mean, 44.5 µg/m3 for PM10, 19.9 µg/m3 for PM2.5–10, and 24.3 µg/m3 for PM2.5) were most strongly associated with an increase in glucose level (percent change by inter-quartile range-change of PM: (β) = 1.4 and p = 0.0023 for PM10; β = 3.0 and p = 0.0010 for PM2.5–10; and β = 2.0 and p = 0.0134 for PM2.5). In particular, elders with PARP4 G-C-G or ERCC1 T-C haplotype were susceptible to PMs exposure in relation to glucose levels (PARP4 G-C-G: β = 2.6 and p = 0.0006 for PM10, β = 3.5 and p = 0.0009 for PM2.5–10, and β = 1.6 and p = 0.0020 for PM2.5; ERCC1 T-C: β = 2.2 and p = 0.0016 for PM10, β = 3.5 and p = 0.0003 for PM2.5–10, and β = 1.2 and p = 0.0158 for PM2.5). Our results indicated that genetic polymorphisms of PARP4 and ERCC1 could modify the relationship between PMs exposure and fasting glucose level in the elderly. Full article
(This article belongs to the Special Issue Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome)
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10 pages, 597 KiB  
Article
Association between Osteoporosis and Previous Statin Use: A Nested Case-Control Study
by So Young Kim, Dae Myoung Yoo, Chanyang Min, Ji Hee Kim, Mi Jung Kwon, Joo-Hee Kim and Hyo Geun Choi
Int. J. Environ. Res. Public Health 2021, 18(22), 11902; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph182211902 - 12 Nov 2021
Cited by 2 | Viewed by 1733
Abstract
The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for [...] Read more.
The relationship between statin use and osteoporosis is controversial; therefore, this study aimed to investigate this association. The ≥40-year-old population of the Korean National Health Insurance Service Health Screening Cohort was enrolled. The 68,592 osteoporosis patients were matched 1:1 with control participants for age, sex, income, and region of residence using propensity score matching. The histories of statin use for two years before the diagnosis of osteoporosis (index date) in the osteoporosis and control groups were compared using conditional/unconditional logistic regression. An increased number of days of statin use was not associated with osteoporosis (adjusted OR (aOR) = 0.97, 95% confidence interval (95% CI) = 0.94–1.00, p = 0.052). In the subgroup analyses, a large number of days of statin use was related to a reduced rate of osteoporosis in the <60-year-old female group, while the opposite was true in the ≥60-year-old female group. Both lipophilic and hydrophilic statins were related to a decreased rate of osteoporosis in the <60-year-old female group. Lipophilic statins, but not hydrophilic statins, were associated with an increased rate of osteoporosis in the ≥60-year-old female group. Statin use showed different associations in middle-aged and elderly women. Full article
(This article belongs to the Special Issue Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome)
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12 pages, 825 KiB  
Article
The Importance of Close Follow-Up in Patients with Early-Grade Diabetic Retinopathy: A Taiwan Population-Based Study Grading via Deep Learning Model
by Chia-Cheng Lee, Shi-Chue Hsing, Yu-Ting Lin, Chin Lin, Jiann-Torng Chen, Yi-Hao Chen and Wen-Hui Fang
Int. J. Environ. Res. Public Health 2021, 18(18), 9768; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18189768 - 16 Sep 2021
Cited by 4 | Viewed by 2071
Abstract
(1) Background: Diabetic retinopathy (DR) can cause blindness. Current guidelines on diabetic eye care recommend more frequent eye examinations for more severe DR to prevent deterioration. However, close follow-up and early intervention at earlier stages are important for the prevention of disease progression [...] Read more.
(1) Background: Diabetic retinopathy (DR) can cause blindness. Current guidelines on diabetic eye care recommend more frequent eye examinations for more severe DR to prevent deterioration. However, close follow-up and early intervention at earlier stages are important for the prevention of disease progression of other diabetes mellitus (DM) complications. The study was designed to investigate the association between different stages of DR in type 2 DM patients and the progression of DR; (2) Methods: A total of 2623 type 2 DM patients were included in this study. In these patients, a total of 14,409 fundus color photographs was obtained. The primary outcome was the progression of DR; (3) Results: The progression of DR was highly associated with the initial grade of DR (p < 0.001). Severe nonproliferative diabetic retinopathy (NPDR) was the most likely to progress to proliferative diabetic retinopathy (PDR), followed by moderate NPDR, mild NPDR, and no retinopathy. However, progression to the next stage of DR showed a different trend. We used no retinopathy as a reference. Mild NPDR showed the highest risk for progression to the next stage [hazard ratio (HR): 2.00 (95% conference interval (CI): 1.72–2.32)] relative to higher initial grades [HR (moderate NPDR): 1.82 (95% CI: 1.58–2.09) and HR (severe NPDR): 0.87 (95% CI: 0.69–1.09)]. The same trend was observed in the multivariate analysis, in which mild NPDR presented the highest risk for progression to the next stage (adjusted HR (mild NPDR): 1.95 (95% CI: 1.68–2.27), adjusted HR (moderate NPDR): 1.73 (95% CI: 1.50–1.99), and adjusted HR (severe NPDR): 0.82 (95% CI: 0.65–1.03)); (4) Conclusions: Type 2 diabetic patients with earlier-grade DR appeared to exhibit more rapid development to the next grade in our study. As these findings show, more frequent fundus color photography follow-up in earlier-grade DR patients is important to slow DR progression and awaken self-perception. Full article
(This article belongs to the Special Issue Advances in Epidemiology and Treatment of Diabetes and Metabolic Syndrome)
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