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Special Issues
Factors Affecting Human Fat Distribution and the Metabolic Health Implications
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Factors Affecting Human Fat Distribution and the Metabolic Health Implications

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4032

Special Issue Editor

Dr. Ursula White

E-Mail Website
Guest Editor
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Interests: adipose tissue; fat distribution; adipose tissue depots; human studies; metabolic health; visceral; abdominal; femoral

Special Issue Information

Dear Colleagues,

Adipose tissue distribution, versus overall obesity, may be a better determinant of metabolic health risk. Preferential accumulation of abdominal fat (visceral and subcutaneous) is associated with obesity-related diseases, while lower-body fat (gluteal and femoral) is associated with lower health risk and may be metabolically protective.

This Special Issue will address this topic and feature the latest research investigating the factors and mechanisms that influence regional human adipose tissue development, distribution, and function. Scholars are invited to contribute novel research findings, approaches, and perspectives, with the aim to better understand the determinants of human fat distribution and the metabolic health implications.

Dr. Ursula White
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Adipose tissue
  • Fat distribution 
  • Adipose tissue depot 
  • Human studies 
  • Abdominal 
  • Visceral 
  • Femoral 
  • Gluteal

Published Papers (1 paper)

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Review

12 pages, 365 KiB  
Review
From an Apple to a Pear: Moving Fat around for Reversing Insulin Resistance
by Maha Alser and Mohamed A. Elrayess
Int. J. Environ. Res. Public Health 2022, 19(21), 14251; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph192114251 - 31 Oct 2022
Cited by 8 | Viewed by 3543
Abstract
Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a proportion of obese individuals who express [...] Read more.
Type 2 diabetes (T2D) is a chronic condition where the body is resistant to insulin, leading to an elevated blood glucose state. Obesity is a main factor leading to T2D. Many clinical studies, however, have described a proportion of obese individuals who express a metabolically healthy profile, whereas some lean individuals could develop metabolic disorders. To study obesity as a risk factor, body fat distribution needs to be considered rather than crude body weight. Different individuals’ bodies favor storing fat in different depots; some tend to accumulate more fat in the visceral depot, while others tend to store it in the femoral depot. This tendency relies on different factors, including genetic background and lifestyle. Consuming some types of medications can cause a shift in this tendency, leading to fat redistribution. Fat distribution plays an important role in the progression of risk of insulin resistance (IR). Apple-shaped individuals with enhanced abdominal obesity have a higher risk of IR compared to BMI-matched pear-shaped individuals, who store their fat in the gluteal-femoral depots. This is related to the different adipose tissue physiology between these two depots. In this review, we will summarize the recent evidence highlighting the underlying protective mechanisms in gluteal-femoral subcutaneous adipose tissues compared to those associated with abdominal adipose tissue, and we will revise the recent evidence showing antidiabetic drugs that impact fat distribution as they manage the T2D condition. Full article
(This article belongs to the Special Issue Factors Affecting Human Fat Distribution and the Metabolic Health Implications)
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