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Industrial Microbiology and Bioprocess Technology
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Industrial Microbiology and Bioprocess Technology

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Microbiology".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 8831

Special Issue Editors

Dr. Stefan Pflügl

E-Mail Website
Guest Editor
Institute for Chemical, Environmental and Bioscience Engineering, Research Area Biochemical Engineering, Technische Universität Wien, Gumpendorfer Straße 1a, 1060 Vienna, Austria
Interests: microbial bioprocess and strain development; continuous bioprocessing; extremophiles; gas fermentation; metabolic engineering
Special Issues, Collections and Topics in MDPI journals
Dr. Hannes Rußmayer

E-Mail Website
Guest Editor
Institue of Microbiology and Microbial Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, 1180 Wien, Vienna
Interests: industrial biotechnology; metabolic engineering; microbial chemical production

Special Issue Information

Dear Colleagues,

Industrial Microbiology deals with the use of microorganisms in industrial processes. These processes include the manufacturing of high-value products such as chemicals, fuels, drugs, and feed additives for the pharmaceutical, chemical, cosmetic, and food and feed industries.

Research in this area primarily focuses on the description and characterization of microbial host systems and their exploitation using bioprocess development. Therefore, strategies to demonstrate the suitability of individual systems for the production of a target compound usually include microbiological tools, genetic engineering for targeted strain enhancement and adaptation, systems-level tools to create understanding of the metabolic network of microorganisms and its regulation, and the use of quantitative bioprocessing technologies to exploit and accentuate the natural abilities of microbial hosts in bioprocesses with the potential for industrial application. Additionally, research on the use of alternative raw materials (ligno- or agro-based feedstocks, gaseous feedstocks, etc.) reflects efforts towards the development of industrially relevant bioprocesses.

We would like to invite authors to submit reviews, mini-reviews, original research articles, and short communications which report progress in the field of Industrial Microbiology and/or Bioprocess Technology or to summarize the current state-of-the-art of one or multiple sub-area(s) of the field.

Topic include but are not limited to the following:

  • Characterization of established microbial production systems or the description of new systems;
  • Studies to improve our understanding of microbial host systems on a physiological and/or systems level;
  • Metabolic engineering of microorganisms to selectively enhance product formation, decrease unwanted by-products, and improve strain fitness and performance;
  • Process development using microorganisms to obtain a high-value product including scale-up studies, studies describing the development of suitable process monitoring and control tools, and studies dealing with process intensification (e.g., continuous bioprocessing).

Dr. Stefan Pflügl
Dr. Hannes Rußmayer
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • industrial microbiology
  • bioprocess technology
  • metabolic engineering
  • microbial metabolic networks and regulation
  • strain robustness and fitness
  • alternative feedstocks
  • fuel and chemical production
  • systems-level analysis
  • process monitoring and control
  • continuous bioprocessing

Published Papers (3 papers)

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Research

18 pages, 6077 KiB  
Article
Melanin: Production from Cheese Bacteria, Chemical Characterization, and Biological Activities
by Ana Rita Ferraz, Rita Pacheco, Pedro D. Vaz, Cristina S. Pintado, Lia Ascensão and Maria Luisa Serralheiro
Int. J. Environ. Res. Public Health 2021, 18(20), 10562; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph182010562 - 09 Oct 2021
Cited by 11 | Viewed by 2285
Abstract
Pigments are compounds of importance to several industries, for instance, the food industry, where they can be used as additives, color intensifiers, and antioxidants. As the current trend around the world is shifting to the use of eco-friendly commodities, demand for natural dyes [...] Read more.
Pigments are compounds of importance to several industries, for instance, the food industry, where they can be used as additives, color intensifiers, and antioxidants. As the current trend around the world is shifting to the use of eco-friendly commodities, demand for natural dyes is increasing. Melanins are pigments that are produced by several microorganisms. Pseudomonas putida ESACB 191, isolated from goat cheese rind, was described as a brown pigment producer. This strain produces a brown pigment via the synthetic Müeller-Hinton Broth. This brown compound was extracted, purified, analyzed by FTIR and mass spectrometry, and identified as eumelanin. The maximum productivity was 1.57 mg/L/h. The bioactivity of eumelanin was evaluated as the capacity for scavenging free radicals (antioxidant activity), EC50 74.0 ± 0.2 μg/mL, and as an acetylcholinesterase inhibitor, with IC50 575 ± 4 μg/mL. This bacterial eumelanin did not show cytotoxicity towards A375, HeLa Kyoto, HepG2, or Caco2 cell lines. The effect of melanin on cholesterol absorption and drug interaction was evaluated in order to understand the interaction of melanin present in the cheese rind when ingested by consumers. However, it had no effect either on cholesterol absorption through an intestinal simulated barrier formed by the Caco2 cell line or with the drug ezetimibe. Full article
(This article belongs to the Special Issue Industrial Microbiology and Bioprocess Technology)
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13 pages, 1985 KiB  
Article
Physiological Characterization of Sulfolobus acidocaldarius in a Controlled Bioreactor Environment
by Kerstin Rastädter, David Johannes Wurm, Oliver Spadiut and Julian Quehenberger
Int. J. Environ. Res. Public Health 2021, 18(11), 5532; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18115532 - 21 May 2021
Cited by 3 | Viewed by 2381
Abstract
The crenarchaeal model organism Sulfolobus acidocaldarius is typically cultivated in shake flasks. Although shake flasks represent the state-of-the-art for the cultivation of this microorganism, in these systems crucial process parameters, like pH or substrate availability, are only set initially, but cannot be controlled [...] Read more.
The crenarchaeal model organism Sulfolobus acidocaldarius is typically cultivated in shake flasks. Although shake flasks represent the state-of-the-art for the cultivation of this microorganism, in these systems crucial process parameters, like pH or substrate availability, are only set initially, but cannot be controlled during the cultivation process. As a result, a thorough characterization of growth parameters under controlled conditions is still missing for S. acidocaldarius. In this study, we conducted chemostat cultivations at 75 °C using a growth medium containing L-glutamate and D-glucose as main carbon sources. Different pH values and dilution rates were applied with the goal to physiologically characterize the organism in a controlled bioreactor environment. Under these controlled conditions a pH optimum of 3.0 was determined. Washout of the cells occurred at a dilution rate of 0.097 h−1 and the optimal productivity of biomass was observed at a dilution rate of 0.062 h−1. While both carbon sources were taken up by S. acidocaldarius concomitantly, a 6.6-fold higher affinity for L-glutamate was shown. When exposed to suboptimal growth conditions, S. acidocaldarius reacted with a change in the respiratory behavior and an increased trehalose production rate in addition to a decreased growth rate. Full article
(This article belongs to the Special Issue Industrial Microbiology and Bioprocess Technology)
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12 pages, 1467 KiB  
Article
Enzymatic Hydrolysate of Cinnamon Waste Material as Feedstock for the Microbial Production of Carotenoids
by Stefano Bertacchi, Stefania Pagliari, Chiara Cantù, Ilaria Bruni, Massimo Labra and Paola Branduardi
Int. J. Environ. Res. Public Health 2021, 18(3), 1146; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18031146 - 28 Jan 2021
Cited by 6 | Viewed by 2993
Abstract
In the context of the global need to move towards circular economies, microbial cell factories can be employed thanks to their ability to use side-stream biomasses from the agro-industrial sector to obtain additional products. The valorization of residues allows for better and complete [...] Read more.
In the context of the global need to move towards circular economies, microbial cell factories can be employed thanks to their ability to use side-stream biomasses from the agro-industrial sector to obtain additional products. The valorization of residues allows for better and complete use of natural resources and, at the same time, for the avoidance of waste management to address our needs. In this work, we focused our attention on the microbial valorization of cinnamon waste material after polyphenol extraction (C-PEW) (Cinnamomum verum J.Presl), generally discarded without any additional processing. The sugars embedded in C-PEW were released by enzymatic hydrolysis, more compatible than acid hydrolysis with the subsequent microbial cultivation. We demonstrated that the yeast Rhodosporidium toruloides was able to grow and produce up to 2.00 (±0.23) mg/L of carotenoids in the resulting hydrolysate as a sole carbon and nitrogen source despite the presence of antimicrobial compounds typical of cinnamon. To further extend the potential of our finding, we tested other fungal cell factories for growth on the same media. Overall, these results are opening the possibility to develop separate hydrolysis and fermentation (SHF) bioprocesses based on C-PEW and microbial biotransformation to obtain high-value molecules. Full article
(This article belongs to the Special Issue Industrial Microbiology and Bioprocess Technology)
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