Special Issue "The Role of Lifestyle in Gastrointestinal Cancer: Prevention, Treatment and Survival"

Special Issue Editors

Dr. Vincenza Gianfredi
E-Mail Website
Guest Editor
School of Medicine Vita-Salute San Raffaele University, Milan, Italy
Interests: epidemiology; cancer prevention; public health; health promotion; lifestyle behavior; health education
Special Issues and Collections in MDPI journals
Dr. Daniele Nucci
E-Mail Website
Guest Editor
Research Dietitian-Nutritionist, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy
Interests: human nutrition; cancer prevention; culinary nutrition; colon cancer; esophageal cancer; Barrett’s esophagus; nutrition education; mental health; health promotion

Special Issue Information

Dear Colleagues,

On behalf of the International Journal of Environmental Research and Public Health (IJERPH), we are organizing a Special Issue on the role of lifestyle in gastrointestinal cancers: prevention, treatment and survival. IJERPH is a peer-reviewed scientific journal that publishes manuscripts in the interdisciplinary area of environmental health sciences and public health.

Gastrointestinal (GI) cancers include five major types of cancers (stomach, liver, esophagus, pancreas, and colorectum) with approximately 5 million new cases and 4 million deaths worldwide in 2018. GI cancers are predicted to increase by 2040. These data highlight the continuing challenge that GI cancers present to public health.

In most cases, these five types of cancers share the same modifiable risk factors, including alcohol consumption, smoking, infection, diet, and obesity, showing a large margin for intervention in prevention, treatment, and survival. In fact, with the exception of colorectal cancer, the prognosis tends to be poor, mostly due to the late-stage diagnoses and reduced treatment options. Considering that the incidence of GI cancers is forecast to increase (from 58% to 73%, in the next decades), and taking into account that most of the risk factors are modifiable and attributable to lifestyle, new studies are needed in order to assess their role in the prevention, treatment, and survival of GI cancers.

This Special Issue of IJERPH focuses on the current state of knowledge on the links between a broad range of lifestyle factors (including but not limited to diet, physical activity, smoking, alcohol consumption) and GI cancers. New research papers, reviews, case reports, and protocol studies are welcome to this Issue. Special attention will be paid to original research (including systematic reviews). Studies do not necessarily have to offer “positive results” (i.e., results confirming previous literature).

Dr. Vincenza Gianfredi
Dr. Daniele Nucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gastrointestinal cancer
  • lifestyle
  • diet
  • cancer prevention
  • cancer treatment
  • cancer survivors

Published Papers (1 paper)

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Association between Dietary Fibre Intake and Colorectal Adenoma: A Systematic Review and Meta-Analysis
Int. J. Environ. Res. Public Health 2021, 18(8), 4168; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18084168 - 15 Apr 2021
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PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were [...] Read more.
PubMed/Medline, Excerpta Medica dataBASE (EMBASE) and Scopus were searched in January 2021 in order to retrieve evidence assessing the association between dietary fibre intake and the risk of colorectal adenoma in adults. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used for the reporting of results. Only primary observational studies were included. Publication bias was estimated through the Egger’s test and the visual inspection of the funnel plot. Heterogeneity between studies was calculated with I2 statistics. The search strategy identified 683 papers, 21 of which were included in our meta-analysis. Having evaluated a total of 157,725 subjects, the results suggest a protective effect of dietary fibre intake against colorectal adenoma. Effect Size (ES) was [0.71 (95% CI = 0.68–0.75), p = 0.000)]. Moderate statistical heterogeneity (Chi2 = 61.68, df = 23, I2 = 62.71%, p = 0.000) was found. Findings show a statistically significant (p = 0.000) and robust association between a higher intake of dietary fibre and a lower risk of colorectal adenoma, considering both the prevalent and incident risk. Moreover, the meta-regression analysis showed a borderline significant negative linear correlation between the amount of dietary fibre intake and colorectal adenoma. Lastly, we performed a subgroup analysis by sex, showing a higher protective effect for men. Full article
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