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Risk Assessment and Preventive Child Health Care during the First 1000 Days from Conception Onwards

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: closed (1 June 2022) | Viewed by 10388

Special Issue Editor


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Guest Editor
University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Interests: life cycle; public health; first 1000 days; prevention and prediction; socioeconomic and ethnic health differences; vulnerable groups; early life stress; nutrition; integration of biological, sociopsychological and environmental pathways; growth, development and cardiometabolic health in childhood; translation into primary and secondary preventive child health care

Special Issue Information

Dear Colleagues,

More and more evidence has arisen that both risk factors and protective factors play an important role during the preconception phase and the first 1000 days from conception onward, potentially leading to lifelong and even transgenerational consequences. These include physical (e.g., malnutrition, mode of delivery), psychosocial (e.g., maternal depression and anxiety, and child abuse), environmental (e.g., smoking exposure), and also medical factors (e.g., the use of antibiotics and folic acid suppletion, known for its protective effects). Exposure to these factors may lead to epigenetic changes or other biological changes (e.g., in brain structure), which have implications for early development and diseases later in life, including neurodevelopmental, neurodegenerative, and immunological diseases.

Little is known regarding to what extent adverse changes are reversible. Therefore, from both an individual level and from a public health perspective, primary (but also secondary) prevention is considerably important, implying that exposure to (accumulation of) risk factors should be reduced and exposure to protective factors be promoted. Therefore, understanding how primary (or secondary) prevention from preconception onward can be realized and, consequently, healthcare costs can be minimized is very relevant for public health research.

This Special Issue of IJERPH, entitled “Risk Assessment and Preventive Child Healthcare during the First 1000 Days from Conception Onward” offers an opportunity to publish high-quality research, reviews, and theoretical notes that further our understanding of the role of primary and secondary prevention of changes originating from the preconception phase and the first 1000 days of life, and which role preventive child healthcare can play. We welcome quantitative, qualitative, and mixed-methods research. Submissions that discuss new knowledge, developments, and innovations in the field of the prevention aiming at the development of children to their full potential are particularly encouraged.

We invite you to submit articles on topics including, but not limited to, the following:

  • Development of primary and secondary preventive interventions in the preconception phase and the first 1000 days of life leading to a reduction of adverse developmental outcomes and diseases later in life;
  • Evaluation of primary and secondary preventive interventions in the preconception phase and the first 1000 days of life leading to a reduction of adverse developmental outcomes and diseases later in life;
  • Innovations in risk assessment and care pathways in the preconception phase and the first 1000 days of life;
  • Assessment of targets for primary and secondary prevention based on integrating several biological, psychosocial, and environmental predictors, mediating or moderating factors;
  • Innovation in the measurement of risks during these phases of life;
  • Cost-effectiveness of preventive interventions in these phases of life;
  • Translation of scientific insights into preventive child healthcare practice and into other practices aiming at prevention.

Dr. Marlou L.A. De Kroon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prevention
  • risk assessment and prediction
  • monitoring
  • preconception
  • perinatal
  • risk and protective factors
  • first 1000 days
  • epigenetic programming
  • brains structure
  • (ir)reversible changes

Published Papers (4 papers)

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Research

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16 pages, 701 KiB  
Article
Prenatal Environmental Exposure to Persistent Organic Pollutants and Reproductive Hormone Profile and Pubertal Development in Dutch Adolescents
by Sietske A. Berghuis, Arend F. Bos, Henk Groen, Wilhelmina H. A. de Jong, Anneke C. Muller Kobold, Lucie Wagenmakers-Huizinga, Pieter J. J. Sauer and Gianni Bocca
Int. J. Environ. Res. Public Health 2022, 19(15), 9423; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19159423 - 01 Aug 2022
Cited by 4 | Viewed by 1674
Abstract
Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), may interfere with hormonal processes. Knowledge about the effects of prenatal exposure to PCBs and their hydroxylated metabolites (OH-PCBs) on pubertal development is limited. Therefore, the aim of the current study was to determine [...] Read more.
Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), may interfere with hormonal processes. Knowledge about the effects of prenatal exposure to PCBs and their hydroxylated metabolites (OH-PCBs) on pubertal development is limited. Therefore, the aim of the current study was to determine whether prenatal environmental PCB and OH-PCB exposure are associated with reproductive hormone levels and pubertal characteristics in 13- to 15-year-old children. In this Dutch observational cohort study, 194 mother–infant pairs were included (1998–2002). Maternal pregnancy serum levels of PCBs, OH-PCBs, and other POPs were measured. At follow-up (2014–2016), we measured serum or plasma levels of reproductive hormones in their children. We assessed Tanner stages and testicular volume (by clinician or standardized self-assessment), and participants completed questionnaires on pubertal onset. In total, 101 adolescents (14.4 ± 0.8 years; 53.7% of invited) participated, and 55 were boys. In boys, higher prenatal PCB levels were associated with higher testosterone levels, higher pubic hair stage, larger testicular volume, and younger age at onset of growth spurt and voice break. In girls, higher prenatal PCB levels were associated with higher stages for breast development. In conclusion, higher prenatal PCB exposure could be associated with more advanced pubertal development in 13- to 15-year-old children. Full article
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15 pages, 662 KiB  
Article
Assessing Concerns and Care Needs of Expectant Parents: Development and Feasibility of a Structured Interview
by Anne van Driessche, Henk F. van Stel, Remy M. Vink and Ingrid I. E. Staal
Int. J. Environ. Res. Public Health 2021, 18(18), 9585; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph18189585 - 11 Sep 2021
Cited by 1 | Viewed by 1573
Abstract
Many adverse situations for parenting and healthy child development can be detected before a child’s birth. The aim of this project was to develop and test an instrument to use in prenatal home visits, to improve the identification of adverse situations and care [...] Read more.
Many adverse situations for parenting and healthy child development can be detected before a child’s birth. The aim of this project was to develop and test an instrument to use in prenatal home visits, to improve the identification of adverse situations and care needs during pregnancy. The preSPARK is based on a valid and reliable broad-scope structured interview called SPARK (Structured Problem Analysis of Raising Kids). The preSPARK focuses on 12 topics ranging from aspects of the period before pregnancy to future parents’ expectations. The preSPARK was tested in daily practice for feasibility and discriminative capacity. User experience was assessed from the perspective of the professional. In total, 64 home visits using the preSPARK were carried out by 21 nurses. About 24% of the expectant parents needed intensive help or immediate action on one or more topics. The risk assessment showed 29% of the participants were at high risk, 40% at increased risk, and 31% at low risk for future parenting and child developmental problems. The nurses indicated that the preSPARK provides a good structure for home visits and gives insight in interrelated factors. The preSPARK is feasible in daily practice and clarifies risks and care needs of expectant parents. Full article
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Review

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23 pages, 838 KiB  
Review
The Impact of Maternal Prenatal Stress Related to the COVID-19 Pandemic during the First 1000 Days: A Historical Perspective
by Sam Schoenmakers, E. J. (Joanne) Verweij, Roseriet Beijers, Hilmar H. Bijma, Jasper V. Been, Régine P. M. Steegers-Theunissen, Marion P. G. Koopmans, Irwin K. M. Reiss and Eric A. P. Steegers
Int. J. Environ. Res. Public Health 2022, 19(8), 4710; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19084710 - 13 Apr 2022
Cited by 17 | Viewed by 5144
Abstract
The COVID-19 pandemic has a major impact on society, particularly affecting its vulnerable members, including pregnant women and their unborn children. Pregnant mothers reported fear of infection, fear of vertical transmission, fear of poor birth and child outcomes, social isolation, uncertainty about their [...] Read more.
The COVID-19 pandemic has a major impact on society, particularly affecting its vulnerable members, including pregnant women and their unborn children. Pregnant mothers reported fear of infection, fear of vertical transmission, fear of poor birth and child outcomes, social isolation, uncertainty about their partner’s presence during medical appointments and delivery, increased domestic abuse, and other collateral damage, including vaccine hesitancy. Accordingly, pregnant women’s known vulnerability for mental health problems has become a concern during the COVID-19 pandemic, also because of the known effects of prenatal stress for the unborn child. The current narrative review provides a historical overview of transgenerational effects of exposure to disasters during pregnancy, and the role of maternal prenatal stress. We place these effects into the perspective of the COVID-19 pandemic. Hereby, we aim to draw attention to the psychological impact of the COVID-19 pandemic on women of reproductive age (15–49 year) and its potential associated short-term and long-term consequences for the health of children who are conceived, carried, and born during this pandemic. Timely detection and intervention during the first 1000 days is essential to reduce the burden of transgenerational effects of the COVID-19 pandemic. Full article
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Other

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12 pages, 345 KiB  
Study Protocol
Connecting Obstetric, Maternity, Pediatric and Preventive Child Health Care: A Comparative Prospective Study Protocol
by Silke Boertien, Arie Franx, Danielle E. M. C. Jansen, Henk Akkermans and Marlou L. A. de Kroon
Int. J. Environ. Res. Public Health 2022, 19(11), 6774; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19116774 - 01 Jun 2022
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Abstract
Collaboration between birth care and Preventive Child Health Care (PCHC) in the Netherlands is so far insufficient. The aim of the Connecting Obstetric; Maternity; Pediatric and PCHC (COMPLETE) study is to: (1) better understand the collaboration between birth care and PCHC and its [...] Read more.
Collaboration between birth care and Preventive Child Health Care (PCHC) in the Netherlands is so far insufficient. The aim of the Connecting Obstetric; Maternity; Pediatric and PCHC (COMPLETE) study is to: (1) better understand the collaboration between birth care and PCHC and its underlying mechanisms (including barriers and facilitators); (2) investigate whether a new multidisciplinary strategy that is developed as part of the project will result in improved collaboration. To realize the first aim, a mixed-method study composed of a (focus group) interview study, a multiple case study and a survey study will be conducted. To realize the second aim, the new strategy will be piloted in two regions in an iterative process to evaluate and refine it, following the Participatory Action Research (PAR) approach. A prospective study will be conducted to compare outcomes related to child health, patient reported outcomes and experiences and quality of care between three different cohorts (i.e., those that were recruited before, during and after the implementation of the strategy). With our study we wish to contribute to a better understanding of collaboration in care and develop knowledge on how the integration of birth care and PCHC is envisioned by stakeholders, as well as how it can be translated into practice. Full article
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