Special Issue "Modern/Advanced Methods of Analysis of Xenobiotic Compounds—Xenobiotics Exposure, Human Health and Ecological Impacts"

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Science and Engineering".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Prof. Dr. Tomasz Tuzimski
E-Mail Website
Guest Editor
Department of Physical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
Interests: theory and application of liquid chromatography; modern extraction techniques (eg., QuEChERS); detection techniques (DAD, FLD, MS, MS/MS); method development and validation; optimisation of chromatographic systems for separation and quantitative analysis of xenobiotics and others (multicomponent mixtures) in food, environmental and biological samples
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Special Issue Information

Dear Colleagues,

In their daily life, humans constantly encounter a huge amount of different substances, including xenobiotics, which are typically synthetic chemicals that are foreign to the body and/or to an ecological system. Xenobiotics can exert adverse effects on human health and increase the incidence of chronic diseases, including cancer, Parkinson’s, Alzheimer’s, multiple sclerosis, diabetes, cardiovascular, chronic kidney disease, and others. As a consequence, the development and validation of analytical methods for xenobiotics has become essential.

Further, in recent years, endocrine disrupting compounds (EDCs) have become the chemical group of special concern due to their ability to interfere with the hormonal system. Bisphenol A (BPA) and its analogs (such as bisphenol S (BPS), bisphenol F (BPF), bisphenol B (BPB), bisphenol C (BPC), bisphenol E (BPE), bisphenol M (BPM), bisphenol P (BPP), bisphenol Z (BPZ), bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol BP (BPBP), bisphenol FL (BPFL), dihydroxydiphenyl ether (DHDPE), and bisphenol A diglycidyl ether (BADGE)) have become the focus of strong concern because of their endocrine-disrupting effects and their widespread occurrence. As indicated in numerous research studies, bisphenols may be washed off the material surface and transferred to food or individual elements of the environment due to the interaction with food ingredients or the influence of external factors.

Moreover, many of these xenobiotics are characterized by lipophilicity; therefore, they are able to easily pass through biological membranes and penetrate living cells and thus be subject to bioaccumulation in various kinds of tissue and organs.

The most efficient approach to xenobiotic analysis involves the use of chromatographic methods. The following chromatographic methods are most frequently applied in environmental/biological samples and food analysis: high-performance liquid chromatography (HPLC), ultrahigh-performance liquid chromatography (UPLC), and gas chromatography (GC).

At present, chromatographic techniques coupled with modern detection techniques can find broad applications in the separation, identification, and quantification of xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, bisphenols, environmental bioindicators, allergens, and others) in different samples.

This Special Issue will present, in a structured manner, state-of-the-art information on the very important field of analytical methods such as high-performance chromatographic techniques coupled with modern detection techniques (e.g., DAD, FLD, mass spectrometry (MS) or tandem mass spectrometry (MS/MS)), biosensors, chips and others applied to analysis of xenobiotics (immuno- and bio- methods).

We are especially interested in research that has practical applications in understanding the nature and role played by xenobiotics in the development of human diseases, influence of xenobiotics on human health, preventive measures, prevention of intensification of disease, biomarkers of different diseases, xenobiotic exposure, the impact of xenobiotics on humans’ environment and their ecological impacts, environmental fate and transport of xenobiotics, and also green chemistry.

We welcome original research papers, critical reviews and short communications. There is no restriction on the length of the papers.

I warmly invite colleagues to submit their original contributions to this Special Issue, which will be of interest to a wide range of readers.

I would be delighted if you could respond to confirm your contribution and the proposed title by 30 June 2020 to assist in planning the whole project. In cases of review articles, an additional brief (1–2 pages) description of the topic including a draft index is required. This preliminary step is essential to avoid overlapping of topics. The degree of novelty and the significance of the research will be scrutinized prior to the peer-reviewing process.

Topics of research of Special Issue:

- Xenobiotic exposure, human health, and ecological impacts;

- Analysis of xenobiotics in food, environmental, and biological samples;

- Analysis of xenobiotics in natural medicines and dietary supplements;

- Analysis of xenobiotics in other natural products and boosters;

- Analysis of xenobiotics in highly processed products and toys;

- Clinical, toxicological, and forensic analytics;

- Industrial analytics with synthesis.

Dr. Tomasz Tuzimski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2300 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Xenobiotics (drugs and veterinary drugs, vitamins, dyes, mycotoxins, environmental bioindicators, allergens, bisphenols, pesticides, and others)
  • Extraction techniques (QuEChERS/d-SPE, SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others)
  • Chromatographic methods (HPLC, UPLC, GC, GC x GC, and others)
  • Detection techniques (DAD, FLD, MS, MS/MS, and others)
  • Other analytical methods
  • Environmental bioindicators
  • Immuno- and bio-(analytical) methods, biosensors, chips and others applied to analysis of xenobiotics

Published Papers (1 paper)

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Application of Solid Phase Extraction and High-Performance Liquid Chromatography with Fluorescence Detection to Analyze Bisphenol A Bis (2,3-Dihydroxypropyl) Ether (BADGE 2H2O), Bisphenol F (BPF), and Bisphenol E (BPE) in Human Urine Samples
Int. J. Environ. Res. Public Health 2021, 18(19), 10307; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph181910307 - 30 Sep 2021
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In this study, we propose a simple, cost-effective, and sensitive high-performance liquid chromatography method with fluorescence detection (HPLC-FLD) for the simultaneous determination of the three bisphenols (BPs): bisphenol A bis (2,3-dihydroxypropyl) ether (BADGE 2H2O), bisphenol F (BPF), and bisphenol E (BPE) [...] Read more.
In this study, we propose a simple, cost-effective, and sensitive high-performance liquid chromatography method with fluorescence detection (HPLC-FLD) for the simultaneous determination of the three bisphenols (BPs): bisphenol A bis (2,3-dihydroxypropyl) ether (BADGE 2H2O), bisphenol F (BPF), and bisphenol E (BPE) in human urine samples. The dispersive solid phase extraction (d-SPE) coupled with solid phase extraction (SPE) procedure performed well for the analytes with recoveries in the range of 74.3–86.5% and relative standard deviations (RSD%) less than 10%. The limits of quantification (LOQs) for all investigated analytes were in the range of 11.42–22.35 ng mL−1. The method was validated at three concentration levels (1 × LOQ, 1.5 × LOQ, and 3 LOQ). During the bisphenols HPLC-FLD analysis, from 6 min a reinforcement (10 or 12) was used, therefore analytes might be identified in the small volume human urine samples. The results demonstrated clearly that the approach developed provides reliable, simple, and rapid quantification and identification of three bisphenols in a urine matrix and could be used for monitoring these analytes. Full article
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