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Special Issue "Alzheimer's disease: From Molecular Basis to Therapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Dr. Greg T. Sutherland
E-Mail Website
Guest Editor
Charles Perkins Centre and School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia
Interests: Neuropathology; brain transcriptomics; neurogenetics; Alzheimer’s disease; alcohol-related brain injury
Prof. Dr. James Duce
E-Mail Website
Guest Editor
ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0AH, UK
Interests: Drug discovery; proteostasis; metal dyshomeostasis; pathological proteins; Alzheimer’s disease

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD) manifests as a chronic deterioration in cognition, primarily in memory, resulting from neuronal loss in specific regions of the brain. Genetics and pathology suggest that beta-amyloid build-up is the key process in the disease, but efforts to pharmaceutically reduce beta-amyloid have not resulted in an expected slowing of cognitive decline. Assuming that amyloid reduction is insufficient for therapeutic relief, other targets are required, and this necessitates new knowledge on AD pathogenesis. In this respect, the increasingly complex multidimensional molecular (multi-omic) data being generated from clinical samples and AD models are both exciting and extremely challenging.  The scope of this Special Issue is an exploration of the different approaches that research groups are using to narrow this knowledge gap around AD pathogenesis. Authors are invited to submit original research or review articles which address linking molecular studies to novel therapeutic avenues or preventive strategies for AD.

Dr. Greg Sutherland
Prof. Dr. James Duce
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Alzheimer’s disease
  • risk factors
  • multi-omics
  • systems biology
  • machine learning
  • clinical samples
  • model systems
  • drug discovery
  • precision medicine and precision prevention

Published Papers

This special issue is now open for submission.
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