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Special Issue "Pathophysiology of AKI from Sepsis to SARS-CoV-2 Infection: Molecular Basis, Diagnosis and Treatment"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Giuseppe Castellano
E-Mail Website
Guest Editor
Nephrology, Dialysis and Transplantation Unit, Università degli Studi di Foggia, Foggia, Italy
Interests: acute kidney injury; sepsis, renal transplantation; complement system; fibrosis and aging; dendritic cells
Special Issues, Collections and Topics in MDPI journals
Dr. Rossana Franzin
E-Mail Website
Guest Editor
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
Interests: acute kidney injury; renal aging; complement system; renal transplantation; endothelial-to-mesenchymal transition
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Stasi
E-Mail Website
Guest Editor
Nephrology Unit, Department of Emergency and Organ Transplantation, University of Bari "Aldo Moro", Bari, Italy
Interests: sepsis; acute kidney injury; infection; molecular biology; animal studies; endothelial dysfunction; inflammation; complement system; fibrosis; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sepsis remains a major cause of morbidity and mortality worldwide, with more than 11 million deaths annually. The syndrome represents a life-threatening systemic disease associated with an overwhelmed host response due to invasion of the bloodstream by bacteria, viruses, fungi, or parasites. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), shares common features with sepsis as multiorgan dysfunction and is currently defined as “viral sepsis”. In recent years, these systemic inflammatory disorders have attracted the interest of several researchers because of their involvement in human health.

In critically ill patients, renal dysfunction is associated with an unacceptably high morbidity/mortality risk, progression toward chronic kidney disease, and increased health resource utilization. Patients with acute kidney injury (AKI) are twice as likely to require invasive mechanical ventilation and renal replacement therapies. Given the paucity of knowledge about optimal prevention and treatment strategies for sepsis and COVID-19-related AKI, specific biological markers for an early and reliable diagnosis of AKI and response to therapies should be defined. This last point is crucial in the management of severe forms of sepsis and COVID-19 and may have an immediate application in our daily approach to these patients. In addition, pre-clinical studies with animal models and in vitro experiments should provide additional insights into the physiopathological aspects of these systemic inflammatory disorders. Exploring new pathogenetic mechanisms, with special regard to the role of soluble and cellular components of innate immunity, would identify novel targets and innovative therapeutic approaches.

In this Special Issue, we will gather original research papers and reviews from different experts in the field that bring to the forefront new advances in pathophysiology and treatment of sepsis and COVID-19-associated AKI.

Prof. Dr. Giuseppe Castellano
Dr. Rossana Franzin
Dr. Alessandra Stasi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Sepsis
  • SARS-CoV-2
  • acute kidney injury (AKI)
  • experimental and clinical studies
  • molecular mechanisms
  • therapeutic targets
  • emerging biomarkers

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