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Special Issue "Molecular Mechanism and Detection of Anti-microbial Resistance in Bacteria"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Donghyuk Kim
E-Mail Website
Guest Editor
Schools of Energy & Chemical Engineering (ECHE) and Life Sciences (SLS), Ulsan National Institute of Science and Technology (UNIST), 50 UNIST-gil, Ulsan 44919, Korea
Interests: systems biology; methanotroph; bacterial pathogens; computational biology; antimicrobial resistance
Prof. Dr. Hae-Yeong Kim
E-Mail Website
Guest Editor
Department of Food Science and Biotechnology, College of Life Sciences, Kyung Hee University, Republic of Korea
Interests: foodborne pathogens; food safety; probiotics; food authenticity; molecular detection
Special Issues and Collections in MDPI journals
Prof. Dr. Hyunjin Yoon
E-Mail Website
Guest Editor
Ajou University, Kyonggi-do, Korea
Interests: bacterial pathogens; virulence; resistance; gene regulation; host–microbe interaction; infectious disease

Special Issue Information

Dear Colleagues,

Emergence of anti-microbial resistance among major bacterial pathogens became a major public health threat affecting humans worldwide. The bacterial resistance to antibiotics includes molecular mechanisms including mutational adaptations, acquisition of genetic material, and alteration of gene expression of resistance genes. These mechanisms implement bacterial adaptation and evolution against antibiotic stress. Thus, investigating biochemical and genetic basis of anti-microbial resistance is important to develop methods to reduce the spread of resistance and to devise effective treatment approaches against antibiotic resistant bacteria.

Dr. Donghyuk Kim
Prof. Dr. Hae-Yeong Kim
Prof. Dr. Hyunjin Yoon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Anti-Microbial Resistance
  • Molecular Resistance Mechanism
  • Resistance Gene
  • Antimicrobial Resistance Transfer
  • Resistance Detection

Published Papers (1 paper)

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Research

Article
Prevalence and Characteristics of Phenicol-Oxazolidinone Resistance Genes in Enterococcus Faecalis and Enterococcus Faecium Isolated from Food-Producing Animals and Meat in Korea
Int. J. Mol. Sci. 2021, 22(21), 11335; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222111335 (registering DOI) - 20 Oct 2021
Viewed by 188
Abstract
The use of phenicol antibiotics in animals has increased. In recent years, it has been reported that the transferable gene mediates phenicol-oxazolidinone resistance. This study analyzed the prevalence and characteristics of phenicol-oxazolidinone resistance genes in Enterococcus faecalis and Enterococcus faecium isolated from food-producing [...] Read more.
The use of phenicol antibiotics in animals has increased. In recent years, it has been reported that the transferable gene mediates phenicol-oxazolidinone resistance. This study analyzed the prevalence and characteristics of phenicol-oxazolidinone resistance genes in Enterococcus faecalis and Enterococcus faecium isolated from food-producing animals and meat in Korea in 2018. Furthermore, for the first time, we reported the genome sequence of E. faecalis strain, which possesses the phenicol-oxazolidinone resistance gene on both the chromosome and plasmid. Among the 327 isolates, optrA, poxtA, and fexA genes were found in 15 (4.6%), 8 (2.5%), and 17 isolates (5.2%), respectively. Twenty E. faecalis strains carrying resistance genes belonged to eight sequence types (STs), and transferability was found in 17 isolates. The genome sequences revealed that resistant genes were present in the chromosome or plasmid, or both. In strains EFS17 and EFS108, optrA was located downstream of the ermA and ant(9)-1 genes. The strains EFS36 and EFS108 harboring poxtA-encoding plasmid cocarried fexA and cfr(D). These islands also contained IS1216E or the transposon Tn554, enabling the horizontal transfer of the phenicol-oxazolidinone resistance with other antimicrobial-resistant genes. Our results suggest that it is necessary to promote the prudent use of antibiotics through continuous monitoring and reevaluation. Full article
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