Special Issue "Renal Na+/K+ ATPase in Regulation of Blood Pressure"
Deadline for manuscript submissions: 31 October 2021.
Na+/K+ ATPase is an energy-dependent enzyme responsible for maintenance of sodium and potassium balance in all living cells. In renal tubules, the sodium pump is restricted to the basolateral membranes and drives the secondary active transport of solutes and ions by maintaining the electrochemical gradient of sodium across the cell membranes. Na+/K+ ATPase is a heterotrimeric enzyme consisting of an a-subunit, a b-subunit, and a FXYD (or g-subunit). The a-subunit, a 110 kDa protein, is the catalytic subunit and the b-subunit, a 36 kDa protein, is required for maturation and insertion of the Na+/K+ ATPase complex into the membrane. The FXYD family of proteins or the g-subunits are tissue-specific and regulate the activity of the pump. To date, four isoforms of the catalytic subunit of Na+/K+ ATPase, the a-subunit (a1–4), have been identified. The a1-subunit is ubiquitously expressed and is the only subunit expressed in the kidneys, while the other isoforms are tissue-specific. Abnormalities in the regulation of Na+/K+ ATPase activity have been implicated in several forms of hypertension. In renal proximal tubules, Na+/K+ ATPase is regulated by parathyroid hormone, dopamine, and angiotensin II. Thus, this Special Issue is directed towards studies understanding the role of renal Na+/K+ ATPase in the regulation of blood pressure.
Dr. Syed J. Khundmiri
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- Na+/K+ ATPase
- Angiotensin II
- Sympathetic activation
- Chronic kidney disease
- Chronic heart failure