Dear Colleagues,

Due to the specific constitution of two different parts with separate embryonic origins (the adrenal cortex producing specific steroid hormones and the adrenal medulla derived from chromaffin tissue contributing to adrenergic tone), the adrenal glands (AGs) are physiologically involved in the regulation of multiple physiological pathways regarding blood pressure behaviors, metabolic regulation, and response to any form of stress. In routine activity, diseases involving AGs vary from non-functional adrenal masses incidentally discovered to alterations due to functional status, especially related to autonomous secretion of the main hormones derived from AGs: primary aldosteronism, Cushing's syndrome, and pheochromocytoma/paraganglioma.

Recent studies also highlight the pivotal role of the adrenal glands in metabolic- and cardiac obesity-related complications, especially the potential role of the fat deposit surrounding the adrenal tumors. Adrenal dysfunction leads to several complications beyond blood pressure regulation, through direct action of different adrenal hormones.

We invite investigators to contribute original research articles as well as review articles that speculate upon and investigate the continuing efforts to understand the clinical relevance, molecular pathology underlying adrenal gland diseases, the development of strategies to diagnose and treat these conditions, and the evaluation of outcomes.

We are particularly interested in articles describing the physiopathological aspects and systemic involvement of hormonal dysfunction due to adrenal diseases and advances in molecular genetics and molecular diagnostics. Potential topics include, but are not limited to:

• Recent developments in diagnosis and management of adrenal gland diseases
• Advances in genetics of adrenal gland diseases
• Latest technologies for clinical evaluation and measuring outcomes
• Role of adrenal hormones in metabolic dysfunction

Prof. Claudio Letizia
Guest Editor

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• adrenal diseases
• primary aldosteronism
• Subclinical hypercortisolism
• Cushing's Syndrome
• pheochromocytoma
• obesity related diseases
• Cardiomiopathy and adrenal disease
• Pheochormocytoma/Paraganglioma Syndrome