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Advances in Spine Oncology 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 4430

Special Issue Editors

Spine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
Interests: spine surgery; spine tumours; degenerative spine disease; mesenchymal stem cells; bone regeneration; disc regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tumors affecting the spine are a challenging pathologic entity that requires the collaboration of multiple medical specialties. The life expectancy of patients affected by tumors of the spine (primary or metastatic) has increased considerably. This is principally due to advances in the field of oncologic therapies and surgical solutions.

Molecular targeted therapy is changing the way we treat cancer. Knowing the molecular signature of a specific tumor can lead to targeted therapy and improved outcomes.

In parallel, the use of spinal surgery has increased considerably worldwide over the last 30 years, leading to the development of new, often minimally invasive, surgical approaches and techniques. Tremendous advances have been made in the field of biomaterials, for example, new carbon fiber implants, 3D-printed prosthesis, or “vertebral transplant” for reconstruction after the resection of tumors from the spine.

This Special Issue will accept articles on molecular research and molecular mechanisms concerning the pathophysiology of spine tumors, molecular and biological therapies, particle therapy, radiation therapy, radiation oncology, new materials, nanoparticles, and interventional radiology. Both basic science articles and reviews are welcome. The issue aims to put together the advances reached in a field which is as multidisciplinary as spine oncology.

Dr. Alessandro Gasbarrini
Dr. Cristiana Griffoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Spine oncology
  • Tumors of the spine
  • Primary tumors
  • Metastatic tumors
  • Molecular signature
  • Molecular and biological therapy
  • Immunotherapy
  • Spondilectomy
  • En bloc resection
  • Particle therapy
  • Radiation oncology

Published Papers (2 papers)

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12 pages, 3286 KiB  
Article
Tumor-Specific Immunoenhancing Effects after Local Cryoablation for Metastatic Bone Tumor in a Mouse Model
by Ryohei Annen, Satoshi Kato, Satoru Demura, Shinji Miwa, Akira Yokka, Kazuya Shinmura, Noriaki Yokogawa, Noritaka Yonezawa, Motoya Kobayashi, Yuki Kurokawa, Toshifumi Gabata and Hiroyuki Tsuchiya
Int. J. Mol. Sci. 2022, 23(16), 9445; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms23169445 - 21 Aug 2022
Cited by 5 | Viewed by 2069
Abstract
We investigated the abscopal effect after cryoablation (CA) on bone metastasis using a mouse model. Breast cancer cells were implanted in the bilateral tibiae of mice. The left tumor was treated locally with CA, and the right abscopal tumor (AT) was left untreated. [...] Read more.
We investigated the abscopal effect after cryoablation (CA) on bone metastasis using a mouse model. Breast cancer cells were implanted in the bilateral tibiae of mice. The left tumor was treated locally with CA, and the right abscopal tumor (AT) was left untreated. The mice were divided into four groups based on the combination of CA and intraperitoneal administration of anti-PD-1 antibody (PD) as treatment interventions (Control, CA, PD, and CA + PD). The reduction ratio of the size of AT, the quantitative immune effects at enzyme-linked immunospot (ELISPOT) assay, and the intensity of infiltration of immune-related cells to AT were compared among the groups. CA alone showed a significant immunoenhancing effect on the volume change ratio of AT from day 0 to day 14 (Control-CA: p < 0.05), ELISPOT assay (Control-CA: p < 0.01), and CD4+ cell count in immunostaining (Control-CA: p < 0.05). CA alone showed no significant immunoenhancing effect on CD8+ and Foxp3+ cell counts in immunostaining, but the combination of CA and PD showed a significant immunoenhancing effect (Control-CA + PD: p < 0.01 [CD8, Foxp3]). The results suggested that the abscopal effect associated with the local cryotherapy of metastatic bone tumors was activated by CA and enhanced by its combination with PD. Full article
(This article belongs to the Special Issue Advances in Spine Oncology 2.0)
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Review

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23 pages, 1154 KiB  
Review
Current and Emerging Approaches for Spine Tumor Treatment
by Bogdan Costăchescu, Adelina-Gabriela Niculescu, Bogdan Florin Iliescu, Marius Gabriel Dabija, Alexandru Mihai Grumezescu and Daniel Rotariu
Int. J. Mol. Sci. 2022, 23(24), 15680; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms232415680 - 10 Dec 2022
Cited by 5 | Viewed by 1963
Abstract
Spine tumors represent a significant social and medical problem, affecting the quality of life of thousands of patients and imposing a burden on healthcare systems worldwide. Encompassing a wide range of diseases, spine tumors require prompt multidisciplinary treatment strategies, being mainly approached through [...] Read more.
Spine tumors represent a significant social and medical problem, affecting the quality of life of thousands of patients and imposing a burden on healthcare systems worldwide. Encompassing a wide range of diseases, spine tumors require prompt multidisciplinary treatment strategies, being mainly approached through chemotherapy, radiotherapy, and surgical interventions, either alone or in various combinations. However, these conventional tactics exhibit a series of drawbacks (e.g., multidrug resistance, tumor recurrence, systemic adverse effects, invasiveness, formation of large bone defects) which limit their application and efficacy. Therefore, recent research focused on finding better treatment alternatives by utilizing modern technologies to overcome the challenges associated with conventional treatments. In this context, the present paper aims to describe the types of spine tumors and the most common current treatment alternatives, further detailing the recent developments in anticancer nanoformulations, personalized implants, and enhanced surgical techniques. Full article
(This article belongs to the Special Issue Advances in Spine Oncology 2.0)
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