Special Issue "Molecular Mechanisms of Aging-Related Neurodegenerative Diseases"
Deadline for manuscript submissions: 30 June 2021.
Interests: Alzheimer’s disease; molecular mechanisms of neurodegeneration; diagnostics; prognostics; biomarkers; machine learning; artificial intelligence
Aging is the main risk factor for many neurodegenerative diseases, including the most common: Alzheimer’s disease and Parkinson’s disease. These diseases are sporadic in the majority of cases, irreversibly escalate with time, and eventually lead to massive neuronal loss. They represent a large, global socioeconomic burden, with no effective therapies available.
Brain cells are especially sensitive to the aging process, but the pathomechanisms switching non-pathological aging to neurodegenerative disorders are complex and not yet fully elucidated. It seems that neurodegeneration develops gradually as a crosstalk between systemic metabolic and inflammatory changes and the brain and involves impairment in the blood–brain barrier and neuroinflammation. Many genetic, epigenetic, and environmental factors, including infectious agents, can contribute to neurodegeneration. Molecular mechanisms of the pathogenesis comprise, but are not limited to, loss of proteostasis, mitochondrial impairment, oxidative stress, cell cycle dysregulation, genomic instability, and calcium dyshomeostasis.
As the elucidation of molecular mechanisms and the sequence of pathological events driving neurodegenerative diseases is crucial for the development of efficient therapies, this Special Issue invites submissions of original research articles and short or comprehensive reviews presenting the current developments in this area. Articles with a therapeutic perspective are especially welcome.
Prof. Dr. Urszula Wojda
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Neurodegenerative diseases
- Alzheimer’s disease
- Parkinson’s disease
- Oxidative stress
- Mitochondrial disorder
- Calcium dyshomeostasis
- Genomic instability
- Epigenetic dysregulation
- Novel therapeutic target