Special Issue "Significance of Antioxidants on Aging and Neurodegeneration"
Deadline for manuscript submissions: 30 September 2021.
Interests: neuroscience; neuropharmacology; antioxidants; neuroinflammation; models of neurodegenerative diseases; aging
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Brain tissue is one of the most vulnerable organs to oxidative stress due to its high content of polyunsaturated fatty acids, oxygen saturation, and iron, in addition to its low antioxidant enzyme activity. Oxidative stress is involved in the pathogenesis of both aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, etc. Usually, it is uncertain if it predisposes or is a consequence of the pathological condition. The therapeutic efficacy of antioxidant treatment has been proven in preclinical and clinical studies. However, the precise mechanism underlying the effects of antioxidants is questioned, specifically as to whether is associated with direct radical scavenger action or the modulation of key signaling pathways related to neurodegeneration.
This Special Issue will involve research manuscripts, reviews, as well as short commentaries on topics related to the underlying mechanism and the role of putative signaling molecules in the effects of different natural and synthetic antioxidants against the pathophysiology of neurodegenerative diseases. It can cover reports from animal models to clinical studies in the field of aging as well as neurodegenerative diseases. Papers focused on the intrinsic role of treatments with antioxidants on oxidative stress and its impact on neurodegeneration will be considered for this Special Issue.
Prof. Dr. Jana Tchekalarova
Prof. Dr. Rumyana Tzoneva
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- neurodegenerative diseases
- signaling pathway