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Special Issue "Natural Products as Anti-Acncer Agents Compared to Synthetic Conventional Chemotherapy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Dr. Ming-Ju Hsieh
E-Mail Website
Guest Editor
Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Interests: apoptosis; autophagy; metastasis; anti-cancer; nature compound; cell biochemistry

Special Issue Information

Dear Colleagues,

Natural products can be isolated from several biological sources, such as plants, fungi, animals and plant cell cultures, among others. Currently, results from many studies have supported the feasibility of herbal medicine and nature food as potent chemopreventive drugs, such as being used as antitumoral and antiangiogenic agents. It has been shown that treatment using natural products with antitumoral and antiangiogenic properties is less toxic to human cells, especially compared to the conventional clinical chemotherapy and radiotherapy. However, there is still a lack of more scientific evidence to support their approbation. Thus, there is a need for more scientific evidence to explore these treatments as they can directly target specific cancers, as well as having potential for improved therapeutic efficacies with reduced toxicities. This Research Topic aims to highlight research on natural products, specifically compounds including terpenes, flavonoids, alkaloids and phytoestrogen, and their cancer-preventive characteristics. This Issue also aims to detail the composition, stability, antiangiogenic potential and/or antitumoral action of biomolecules. Research may include natural products derived from biological sources with some chemical modifications. Antitumoral modalities of natural products can be demonstrated using in vivo models. This must be supported in at least two well-authenticated cancer cell lines.

Dr. Ming-Ju Hsieh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • antitumoral
  • new drugs
  • mechanisms of action

Published Papers (1 paper)

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Research

Open AccessArticle
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial–Mesenchymal Transition
Int. J. Mol. Sci. 2021, 22(9), 5012; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22095012 - 09 May 2021
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Abstract
Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe [...] Read more.
Advanced-stage oral cancers with lymph node metastasis are associated with poor prognosis and a high mortality rate. Although recent advancement in cancer treatment has effectively improved the oral cancer prognosis, the majority of therapeutic interventions are highly expensive and are associated with severe sideeffects. In the present study, we studied the efficacy of a diarylheptanoid derivative, platyphyllenone, in modulating the metastatic potential of human oral cancer cells. Specifically, we treated the human oral cancer cells (FaDu, Ca9-22, and HSC3) with different concentrations of platyphyllenone and measured the cell proliferation, migration, and invasion. The study findings revealed that platyphyllenonesignificantly inhibited the motility, migration, and invasion of human oral cancer cells. Mechanistically, platyphyllenone reduced p38 phosphorylation, decreased β-catenin and Slug, increased E-cadherin expression, and reduced cathepsin L expression, which collectively led to a reduction in cancer cell migration and invasion. Taken together, our study indicates that platyphyllenone exerts significant anti-metastatic effects on oral cancer cells by modulating cathepsin L expression, the MAPK signaling pathway, and the epithelial–mesenchymal transition process. Full article
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