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Special Issue "Antitumor Activities of Natural Compounds from Plants 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editor

Dr. Paola Poma
E-Mail Website
Guest Editor
Department of Biological, Università degli Studi di Palermo, Palermo, Italy
Interests: pharmacology; cancer; antitumor drugs; natural compounds; syntetic molecules; drug delivery; molecular mechanisms; pharmacogenetics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Plants have always been known to be an invaluable source of compounds with multiple pharmacological activities. Although over the centuries the attention towards natural products has undergone various fluctuations, today, many people prefer to use “natural” treatments for different diseases. For example, substances such as essential oils (EOs) and dietary polyphenolic compounds are very present in the cosmetic scene and as home products or food supplements, as well as attracting significant interest due to their anti-inflammatory, anti-mitotic, antibacterial, and anti-proliferative properties. In particular, concerning neoplastic disease, many natural substances from plants seem to have anti-proliferative and pro-apoptotic capacities and, in many cases, multi-target activity that allows them to affect different pathways that are deregulated in cancer cells and to bypass multidrug resistance mechanisms. Moreover, these substances are characterized by low toxicity and sometimes also by high lipid solubility.

This Special Issue of IJMS will focus on the antitumor activities of functional molecular substances derived from plants on all types of neoplastic disease. Topics of particular interest include descriptive analyses of their activities, molecular investigations on the mechanisms of action, evaluations of their efficacy compared to toxicity, and finally, drug delivery studies.

Dr. Paola Poma
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • antitumor activity
  • natural substances
  • plant

Published Papers (3 papers)

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Review

Review
Cancer Therapy Challenge: It Is Time to Look in the “St. Patrick’s Well” of the Nature
Int. J. Mol. Sci. 2021, 22(19), 10380; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221910380 - 26 Sep 2021
Viewed by 438
Abstract
Cancer still remains a leading cause of death despite improvements in diagnosis, drug discovery and therapy approach. Therefore, there is a strong need to improve methodologies as well as to increase the number of approaches available. Natural compounds of different origins (i.e., from [...] Read more.
Cancer still remains a leading cause of death despite improvements in diagnosis, drug discovery and therapy approach. Therefore, there is a strong need to improve methodologies as well as to increase the number of approaches available. Natural compounds of different origins (i.e., from fungi, plants, microbes, etc.) represent an interesting approach for fighting cancer. In particular, synergistic strategies may represent an intriguing approach, combining natural compounds with classic chemotherapeutic drugs to increase therapeutic efficacy and lower the required drug concentrations. In this review, we focus primarily on those natural compounds utilized in synergistic approached to treating cancer, with particular attention to those compounds that have gained the most research interest. Full article
(This article belongs to the Special Issue Antitumor Activities of Natural Compounds from Plants 2.0)
Review
Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
Int. J. Mol. Sci. 2021, 22(11), 5938; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22115938 - 31 May 2021
Cited by 1 | Viewed by 874
Abstract
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. [...] Read more.
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment. Full article
(This article belongs to the Special Issue Antitumor Activities of Natural Compounds from Plants 2.0)
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Review
Selected Monocyclic Monoterpenes and Their Derivatives as Effective Anticancer Therapeutic Agents
Int. J. Mol. Sci. 2021, 22(9), 4763; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22094763 - 30 Apr 2021
Viewed by 724
Abstract
Terpenes—a diverse group of secondary metabolites—constitute the largest class of natural products abundant in almost every plant species. The properties of concrete terpenes and essential oils have been intensively studied due to their widespread use in the pharmaceutical, food and cosmetics industries. Despite [...] Read more.
Terpenes—a diverse group of secondary metabolites—constitute the largest class of natural products abundant in almost every plant species. The properties of concrete terpenes and essential oils have been intensively studied due to their widespread use in the pharmaceutical, food and cosmetics industries. Despite the popularity of these aromatic compounds, their derivatives, terpenoids, are still not comprehensively characterized despite exhibiting potent bioactive properties. This review aims to assess the anticancer properties of selected monoterpenes including carvone, carvacrol, perillyl alcohol, perillaldehyde, limonene, menthol and their derivatives while also evaluating potential applications as novel anticancer treatments. Special attention is paid to functional groups that improve the bioactivity of monoterpene molecules. This review also covers the therapeutic potential of deep eutectic solvents that contain monoterpene substances. Taken together, the literature supports the use of monoterpene derivatives in the development of new alternatives for disease treatment and prevention. Full article
(This article belongs to the Special Issue Antitumor Activities of Natural Compounds from Plants 2.0)
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