Special Issue "Control of Astrocytes Function and Phenotype: Role in Neuropathology"
Deadline for manuscript submissions: 31 August 2021.
Interests: glial cells; neuroprotection; Parkinson’s disease; ischemia; neurotrophic factors; neuroinflammation; electromagnetic stimulation; aging; G protein–coupled estrogen receptor 1 (GPER or GPR30); STEP
Interests: Astrocytes; G protein–coupled estrogen receptor 1; repetitive transcranial magnetic stimulation; ischemia; neurite degeneration; neurons; oxygen and glucose deprivation; primary cortical cultures; synaptic plasticity
Until a couple of decades ago, astrocytes were underrated cells, with experimental studies relying on neurocentric approaches. However, over recent years, more functions and interactions between astrocytes and other cells have been revealed. Through an amazing multiplicity of functions encompassing trophic and energy support, maintenance of synapses, or control of neurogenesis, among others, astrocytes perform key functions in the maintenance and protection of the CNS. On the other hand, increasing data suggest that the dysregulation of astrocytes, or their senescence, may also have a significant contribution to pathological situations. Moreover, during the last few years, it has been shown that these multitasking cells display distinctive functional, morphological, and phenotypical heterogeneity across and within the regions of the CNS. Although the control of astrocyte diversity as well as its contribution to neuropathology is still poorly characterized, it seems increasingly evident that the modulation of astrocyte properties is a promising strategy to induce neuroprotection and neurorepair. However, to achieve this purpose, it is crucial to continue unveiling the cellular and molecular mechanisms that control astrocyte diversity.
This Special Issue on “Control of astrocytes function and phenotype: role in neuropathology” from the International Journal of Molecular Sciences aims to provide a summary of the ultimate advances in this area, with special emphasis on the molecular mechanisms through which it may be possible to modulate astrocytes' protective or deleterious effects on brain disorders. This Special Issue will publish original research articles as well as comprehensive reviews, including current understanding of molecular mechanisms involved in astrocytes modulation.
Dr. Graça Baltazar
Dr. Cláudio Roque
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Astrocyte diversity
- Astrocyte modulation
- Astrocyte-microglia interplay
- Neurologic and Neuropsychiatric disorders
- Neuron–astrocyte interactions Neurorepair