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Special Issue "Autophagy: New Frontier and Perspective"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Dr. Maurizio Battino
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Guest Editor
1. Department of Odontostomatologic and Specialized Clinical Sciences, Sez-Biochimica, Faculty of Medicine, Università Politecnica delle Marche, Via Ranieri 65, 60100 Ancona, Italy
2. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China
Interests: nutrition; bioactive compounds; polyphenols; antioxidants; free radicals; aging; mitochondrial functionality
Special Issues and Collections in MDPI journals
Dr. Francesca Giampieri
grade E-Mail Website
Guest Editor
Department of Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, 60131 Ancona, Italy
Interests: nutrition; health; disease prevention; dietary bioactive compounds; oxidative stress; aging; mitochondrial functionality; inflammation; bioenergetics
Special Issues and Collections in MDPI journals
Dr. Danila Cianciosi
E-Mail Website
Guest Editor
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
Interests: cancer stem cells; natural compounds; bioactive compounds; cancer; polyphenols; vitamins; dietary supplements; self-renewal; chemosensibilization; functional foods; antioxidants; dietary supplementation; human health; chronic diseases; prevention; chemoresistance; metastasis; tumor
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Autophagy is a highly conserved and essential process, which represents one of the main mechanisms for regulating the turnover of cellular components of the cytoplasm and selective removal of damaged organelles or misfolded/aggregated proteins. There are different types of autophagy, but in any case, the degradation of cellular components occurs through the action of lysosomes. The autophagy process is basically governed by a group of genes called ATG (autophagy-related genes). Autophagy controls different physiological processes but is also involved in many processes that lead to the development of different pathologies. In recent years, a crucial role of this self-degradative homeostatic process has been found on events related to inflammation and immunity. Its correct modulation could therefore counteract those conditions that lead to the onset of a large spectrum of immune-mediated inflammatory disease (IMID).

The main purpose of the special issue: “Autophagy: New Frontier and Perspective” is to be an open forum where researchers have the possibility to share their investigations and findings in this field. Contributions to this issue, both in the form of original research or review articles, may cover all aspects of the involved molecular mechanisms and of the effect of drugs or natural compounds on regulate the autophagy process related to IMID.

Dr. Maurizio Battino
Dr. Francesca Giampieri
Dr. Danila Cianciosi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • autophagy
  • immune-mediated diseases
  • IMID
  • inflammatory diseases
  • inflammation
  • autoimmune diseases
  • infections
  • diabetes
  • metabolic disorders
  • infectious diseases
  • allergy
  • aging
  • cardiovascular diseases
  • neurological diseases
  • lupus erythematosus, psoriasis
  • rheumatoid arthritis
  • inflammatory bowel disease
  • multiple sclerosis
  • alopecia areata
  • viral infection
  • bacterial infection

Published Papers (1 paper)

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NOP53 Suppresses Autophagy through ZKSCAN3-Dependent and -Independent Pathways
Int. J. Mol. Sci. 2021, 22(17), 9318; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22179318 - 27 Aug 2021
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Autophagy is an evolutionally conserved process that recycles aged or damaged intracellular components through a lysosome-dependent pathway. Although this multistep process is propagated in the cytoplasm by the orchestrated activity of the mTOR complex, phosphatidylinositol 3-kinase, and a set of autophagy-related proteins (ATGs), [...] Read more.
Autophagy is an evolutionally conserved process that recycles aged or damaged intracellular components through a lysosome-dependent pathway. Although this multistep process is propagated in the cytoplasm by the orchestrated activity of the mTOR complex, phosphatidylinositol 3-kinase, and a set of autophagy-related proteins (ATGs), recent investigations have suggested that autophagy is tightly regulated by nuclear events. Thus, it is conceivable that the nucleolus, as a stress-sensing and -responding intranuclear organelle, plays a role in autophagy regulation, but much is unknown concerning the nucleolar controls in autophagy. In this report, we show a novel nucleolar–cytoplasmic axis that regulates the cytoplasmic autophagy process: nucleolar protein NOP53 regulates the autophagic flux through two divergent pathways, the ZKSCAN3-dependent and -independent pathways. In the ZKSCAN3-dependent pathway, NOP53 transcriptionally activates a master autophagy suppressor ZKSCAN3, thereby inhibiting MAP1LC3B/LC3B induction and autophagy propagation. In the ZKSCAN3-independent pathway, NOP53 physically interacts with histone H3 to dephosphorylate S10 of H3, which, in turn, transcriptionally downregulates the ATG7 and ATG12 expressions. Our results identify nucleolar protein NOP53 as an upstream regulator of the autophagy process. Full article
(This article belongs to the Special Issue Autophagy: New Frontier and Perspective)
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