Dear colleagues,

Autophagy and selective autophagy, such as mitophagy and ER-phagy, have been implicated in the development and progression of a growing number of diseases. Several studies have shown that autophagy is compromised with age and its dysregulation may significantly contribute to the development of age-associated pathologies, as it happens in Alzheimer’s disease or in many tumors. Many aspects of its role in the onset of several diseases have been clarified; however, many more questions remain unanswered, and often, its exact role in the process of neurodegenerative diseases is still under debate.

Thus, this Special Issue aims to review advances in the field of autophagy and its role in age-associated pathologies, including Alzheimer’s disease, Parkinson, amyotrophic lateral sclerosis, liver diseases, diabetes, metabolic diseases, and cancer, with the purpose of better characterizing the molecular dysregulations affecting the autophagic pathway that could underlie the development and progression of the disease.

Dr. Matteo Bordi
Guest Editor

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• Autophagy
• Mitophagy
• Lysosome
• Neurodegenerative diseases
• Cancer
• Oxidative stress
• Mitochondrial metabolism
• ER-phagy