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Special Issue "Autophagy and Age-Associated Pathologies"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Dr. Matteo Bordi
E-Mail Website
Guest Editor
Department of Biology, University of Rome Tor Vergata, Rome, Italy
Interests: autophagy; mitophagy; lysosome; neurodegenerative diseases; Alzheimer; rare genetic diseases; Down syndrome

Special Issue Information

Dear colleagues,

Autophagy and selective autophagy, such as mitophagy and ER-phagy, have been implicated in the development and progression of a growing number of diseases. Several studies have shown that autophagy is compromised with age and its dysregulation may significantly contribute to the development of age-associated pathologies, as it happens in Alzheimer’s disease or in many tumors. Many aspects of its role in the onset of several diseases have been clarified; however, many more questions remain unanswered, and often, its exact role in the process of neurodegenerative diseases is still under debate.

Thus, this Special Issue aims to review advances in the field of autophagy and its role in age-associated pathologies, including Alzheimer’s disease, Parkinson, amyotrophic lateral sclerosis, liver diseases, diabetes, metabolic diseases, and cancer, with the purpose of better characterizing the molecular dysregulations affecting the autophagic pathway that could underlie the development and progression of the disease.

Dr. Matteo Bordi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Autophagy
  • Mitophagy
  • Lysosome
  • Neurodegenerative diseases
  • Cancer
  • Oxidative stress
  • Mitochondrial metabolism
  • ER-phagy

Published Papers

This special issue is now open for submission.
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