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Special Issue "Bacterial Transcriptome and Non-coding RNA"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. Yuri Gogolev
Guest Editor
Kazan Institute of Biochemistry and Biophysics of the Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russia
Interests: plant–microbe interactions; plant microbiome analysis by metagenomics; plant transcriptome analysis; bacteria transcriptome analysis; microRNA

Special Issue Information

Dear Colleagues,

Transcriptomics are a powerful way to estimate the physiological state of either eukaryotic or bacterial cells. Microbial transcriptome and metatranscriptome information is important for quantifying gene expression changes, predicting resistance to antibiotics, and understanding host–pathogen immune interactions. At the same time, less publications are devoted to bacterial transcriptomes than eukaryotic ones. Transcriptional profiling of bacteria is challenging because bacterial RNAs are intrinsically labile. The absence of a poly(A) tail in functional bacterial transcripts precludes the straightforward reverse transcription strategy to selectively enrich mRNAs and concomitantly deplete ribosomal RNAs. The simultaneous profiling of host and pathogen transcriptomes and single-cell transcriptomics is hampered by the low abundance of bacterial mRNA. In addition, despite the relatively simple structure of bacterial genomes, their transcriptomes are incredibly complex. Through newly developed RNA-seq strategies, hundreds of transcription start sites have been found inside operons and opposite to annotated genes. This indicates that the complexity of the gene expression from a small bacterial genome is increased by polycistron separation and genome-wide antisense transcription. While these strategies provide vast amounts of information about bacterial transcriptomes, they also raise challenges regarding the functions of the identified transcripts. Papers related to any aspect of microbial transcriptome, metatranscriptome, dual transcriptional profiling of host and bacteria, and bacterial non-coding RNA will be considered for this Special Issue.

Dr. Yuri Gogolev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bacterial transcriptome
  • metatranscriptome
  • RNA-seq
  • non-coding RNA
  • transcription start sites

Published Papers

This special issue is now open for submission.
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