Special Issue "Advances in Bcl-xL Research 2.0"
Deadline for manuscript submissions: 30 June 2021.
Interests: survival; aging; apoptosis; tumorigenesis; autophagy; deamidation; membrane protein structure
Special Issues and Collections in MDPI journals
The oncogene Bcl-xL is an anti-apoptotic member of the Bcl-2 family that was established as a major survival factor in erythroid lineage and neuronal cells. More recently, Bcl-xL also emerged as being responsible for the resistance of malignant tumor cells to anti-cancer treatments. Over the last decade, refined description of its regulation revealed that several mechanisms are at work that make Bcl-xL instrumental in the control of survival, proliferation, and differentiation. These mechanisms comprise post-translational modifications, the dynamic interactions this protein establishes with its target membranes, and also its interactions with binding partners within and outside the Bcl-2 family of proteins. This Special Issue of IJMS will focus on how Bcl-xL is regulated at the protein level, its organization in the membrane, the plasticity of its interactome, and how it warrants a diversity of cellular functions controlled by Bcl-xL in physiology and pathology. Articles submitted can either provide a review of specific points of the literature, or be original works offering significant advances in the structure and functions of Bcl-xL.
Dr. Muriel Priault
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Survival, proliferation, and differentiation
- Mechanisms of tumor progression
- Mitochondria/endoplasmic reticulum interplay
- Membrane insertion/protein oligomerization
- Targeted drug design
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The role of Bcl-xL in platelet production and life span: implications for human platelet diseases
Authors: Emma C. Josefsson; William Vainchenker; Chloe James
Affiliation: Inserm 1034
Abstract: Blood platelets have important roles in haemostasis, where they quickly stop bleeding in response to vascular damage. They have also recognised functions in thrombosis, immunity, antimicrobal defense, cancer growth and metastasis, tumour angiogenesis, lymphangiogenesis, inflammatory diseases, wound healing, liver regeneration and neurodegeneration. Their brief life span in circulation is strictly controlled by intrinsic apoptosis, where the pro-survival Bcl-2 family protein, Bcl-xL, has a major role. Blood platelets are produced by large polyploid precursor cells, megakaryocytes, residing mainly in the bone marrow. Together with Mcl-1, Bcl-xL regulates megakaryocyte survival. This review describes megakaryocyte maturation and survival, platelet production, platelet life span and diseases of abnormal platelet number with a focus on the role of Bcl-xL during these processes.