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Recent Advances of Bioactive Compounds in Pharmaceutical Designs for Treating Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3151

Special Issue Editor


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Guest Editor
Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
Interests: Pharmaceutical cosmetology and cosmeceutical research; photoprotective mechanism; active compounds in skin care

Special Issue Information

Dear Colleagues,

In the past few decades, many publications have confirmed that stimulants can cause skin diseases, including skin cancer, dermatitis, psoriasis, acne, and skin infections. Bioactive compounds, such as flavonoids, tannic acids, and stilbene compounds in plants, fruits, and vegetables, are commonly added in skin care products to prevent many skin diseases. It is very important to know how to use the delivery systems for increasing the skin absorption of bioactive compounds and presenting better pharmacological activity. In this regard, for the Special Issue concerning “Recent Advances of Bioactive Compounds in Pharmaceutical Designs for treating skin diseases”, researchers are kindly invited to submit original papers, communications, and reviews in this field, with a focus on all aspects of the mechanisms of molecular biological activity, physicochemical characterizations, and skin absorption improvement, in order to develop skin care products able to prevent stimulants-induced skin diseases.

Dr. Feng-Lin Yen
Guest Editor

Manuscript Submission Information

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Keywords

  • Bioactive compounds
  • flavonoids
  • tannic acids
  • stilbene compounds
  • skin disease
  • skin cancer
  • dermatitis
  • psoriasis
  • acne
  • skin infection

Published Papers (1 paper)

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Review

23 pages, 2904 KiB  
Review
Recent Advancements in Topical Anti-Psoriatic Nanostructured Lipid Carrier-Based Drug Delivery
by Tulshidas S. Patil, Nayan A. Gujarathi, Abhijeet A. Aher, Hemal E. Pachpande, Charu Sharma, Shreesh Ojha, Sameer N. Goyal and Yogeeta O. Agrawal
Int. J. Mol. Sci. 2023, 24(3), 2978; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24032978 - 03 Feb 2023
Cited by 9 | Viewed by 2771
Abstract
Psoriasis is linked with unusual differentiation and hyperproliferation of epidermal keratinocytes that significantly impair the quality of life (QoL) of patients. The present treatment options only provide symptomatic relief and are surrounded by various adverse effects. Recently, nanostructured lipid carriers (NLCs) have emerged [...] Read more.
Psoriasis is linked with unusual differentiation and hyperproliferation of epidermal keratinocytes that significantly impair the quality of life (QoL) of patients. The present treatment options only provide symptomatic relief and are surrounded by various adverse effects. Recently, nanostructured lipid carriers (NLCs) have emerged as next-generation nanocarriers with better physicochemical characteristics. The current manuscript provides background information on psoriasis, its pathophysiology, existing treatment options, and its limitations. It highlights the advantages, rationale, and mechanism of the permeation of NLCs for the treatment of psoriasis. It further gives a detailed account of various NLC nanoformulations for the treatment of psoriasis. In addition, tabular information is provided on the most relevant patents on NLCs for treating psoriasis. Lastly, light is shed on regulatory considerations related to NLC-like nanoformulations. In the treatment of psoriasis, NLCs display a sustained release drug profile, an ability to incorporate both hydrophobic and hydrophilic drugs, an enhancement in skin hydration, penetrability, retention, and bioavailability of the drug, along with reduced staining potential as compared to conventional ointments, and decreased side effects of drug molecules. This affirms the bright future of NLC nanoformulations in the treatment of psoriasis. However, academic industry collaboration and more sound regulatory controls are required to commercialize the NLC nanoformulations for psoriasis treatment. Full article
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