Dear Colleagues,

Bioactive compounds derived from natural products include a diverse class of compounds with different chemical structures comprising polyphenols, carotenoids, tocopherols, phytosterols, organosulfur compounds, and other classes. While many of them are not essential, their substantial proportion may modulate a number of processes ongoing in our body and are useful in the prevention and therapy of various human disorders. Although several bioactive compounds are reported to have a beneficial effect on vision, the results of clinical trials and systematic reviews on their efficacy in various eye diseases are not conclusive. Therefore, studies on the effects of bioactive compounds in eye diseases are needed and should primarily focus on the involvement of bioactive compounds in pathogenesis mechanisms and preventive and therapeutic potential.

This Special Issue welcomes both original papers and reviews addressing the potential of bioactive compounds in eye disease pathogenesis, prevention, and therapy. The following diseases may be addressed: refractive disorders, dry eye syndrome, cornea degenerations and dystrophies, conjunctiva disorders, cataracts, uveitis, glaucoma, age-related macular degeneration, diabetic retinopathy, albinism, retinopathy of prematurity, retinitis pigmentosa, ocular tumors, lysosomal storage diseases, and rare ophthalmic genetic diseases, as well as chemical and physical damage of the eye studied in cell cultures, animal models, or human material. The following keywords may be useful in selecting a paper topic.

Keywords (all in relation to bioactive compounds in eye diseases):

• Pathogenesis, prevention, and therapy
• Bioavailability
• Genetic/epigenetic
• Oxidative stress and antioxidant system
• Stress response
• Molecular chaperones
• Senescence and organismal aging
• Mitochondrial quality control
• Autophagy and mitophagy
• DNA damage reaction in the nucleus and mitochondria
• DNA damage and repair
• Mutations/polymorphisms of genes
• Programmed cell death, including apoptosis, pyroptosis, and necroptosis
• Inflammation and the inflammasome activation
• miRNA-lncRNA regulation

Prof. Dr. Kai Kaarniranta
Prof. Dr. Janusz Blasiak
Guest Editors

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• Bioactive Compounds in the Pathogenesis, Prevention, and Therapy of Eye Diseases in International Journal of Molecular Sciences (6 articles)