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Special Issue "Synthesis and Transformations of Bioactive Hydroxyquinolines"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Prof. Dr. István Szatmári
E-Mail Website
Guest Editor
Institute of Pharmaceutical Chemistry, University of Szeged (SZTE), Szeged, Hungary
Interests: 8-quinolinols; 4-hydroxyquinoline-2-carboxylic acid (KYNA); drug design and synthesis; indole derivatives; ortho-quinone methides; modified Mannich reaction; modified aza-Friedel-Crafts reaction

Special Issue Information

Dear Colleagues,

We are delighted to announce a call for submissions to a Special Issue of the International Journal of Molecular Sciences on the topic of “Synthesis and Transformations of Bioactive Hydroxyquinolines”.

Privileged structures can bind to a diverse range of targets with high affinities, thus benefitting the discovery of novel bioactive agents. Hydroxyquinoline derivatives represent an important type of such a privileged structure, possessing a rich diversity of biological properties.

One participant of such compounds is 4-hydroxyquinoline-2-carboxylic acid (kynurenic acid or KYNA). It is one of the few endogenous excitatory amino acid receptor blockers, produced via the metabolism of tryptophan (TRP). It is well established that KYNA has high affinity toward NMDA receptors and a high affinity toward positive modulatory binding sites at the AMPA receptor that are assumed to be the reasons for its biological effects.

On the other hand, 8-hydroxyquinoline itself or its derivatives have a broad pharmacological activity and have been exploited in several medicinal applications ranging from anti-neurodegenerative, anti-inflammatory, and antimicrobial to anticancer therapies.

We encourage the submission of both original research articles and topical reviews on all aspects of synthesis and pharmacological studies on hydroxyquinoline derivatives. All submitted articles will undergo peer review.

Prof. Dr. István Szatmári
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • hydroxyquinolines
  • 8-quinolinols
  • 4-hydroxyquinoline-2-carboxylic acid (KYNA)
  • bioactive compounds
  • neuroprotection
  • antiproliferative activity

Published Papers

This special issue is now open for submission.
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