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Topical Collection "Bioactive Phytochemicals: Biosynthesis and Functional Role In Planta, and Health-Promoting Effects in Animals and Humans"

Editor

Prof. Dr. Marcello Iriti
E-Mail Website
Collection Editor
Department of Agricultural and Environmental Sciences, Milan State University, Milan, Italy
Interests: environmental pollution; agrochemicals; mycotoxins; biomonitoring
Special Issues and Collections in MDPI journals

Topical Collection Information

Dear Colleagues,

In evolutionary terms, phytochemical diversity determined the success of plant organisms as well as their adabtability to a changing (and challenging) environment. Indeed, plants are sessile organisms not able to escape from stressfull conditions such as high light and UV radiations, extreme meteorological events, adverse climatic conditions, pollutants, pathogens and phytophages. In these scenario, secondary metabolites protect plant from biotic, abiotic and environmental stresses, by virtue of their antimicrobial, antifeedant and antioxidant activities just to name a few. Since plants represent a staple food source for animals (including humans), the latter have been exposed to phytochemicals from the time of their appearance on earth. Therefore, a coevolution between human and plant bioactives - that are xenobiotics - occurred. In the last decades, a huge amount of preclinical (i.e. in vitro and in vivo) studies indicated that phytochemicals exert a plethora of biological and pharmacological activities in cell cultures and animal models, though the evidence in humans is less substantiated and still fragmentary. Nowdays, we know that bioactive phytochemicals possess antimicrobial, anti-inflammatory, antioxidant/prooxidant, cytotoxic and immunomodulating activities, inter alia, which make them promising cardioprotective, neuroprotective, anticancer, antidiabetes, antiobesity and antiaging agents. However, phytochemicals appear to be more effective in prevention than in treatment of chronic-degenerative diseases. This is the case of healthy diets rich in plant foods. Not least, phytochemicals can be used as adjuvants in association with conventional therapies in order to improve their efficacy, reduce their adverse effects, decrease the risk of selecting resistant microbial strains or cancer cells or even revert resistance.

In this very wide context, we invite investigators to submit both original research and review articles that explore all these aspects.

Prof. Dr. Marcello Iriti
Collection Editor

Manuscript Submission Information

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Keywords

  • stress physiology
  • plant secondary metabolism/metabolites
  • biotic/abiotic/environmental stresses
  • global climate change
  • nutraceuticals
  • functional foods
  • medicinal plants
  • botanicals
  • plant extracts
  • essential oils
  • marine drugs
  • one health
  • antimicrobial resistance
  • antineoplastic resistance
  • metabolomics
  • ethnopharmacology

Published Papers (2 papers)

2021

Review
Eleutherine bulbosa (Mill.) Urb. Bulb: Review of the Pharmacological Activities and Its Prospects for Application
Int. J. Mol. Sci. 2021, 22(13), 6747; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136747 - 23 Jun 2021
Viewed by 439
Abstract
Natural product is an excellent candidate for alternative medicine for disease management. The bulb of E. bulbosa is one of the notable Iridaceae family with a variety therapeutic potential that is widely cultivated in Southeast Asia. The bulb has been used traditionally among [...] Read more.
Natural product is an excellent candidate for alternative medicine for disease management. The bulb of E. bulbosa is one of the notable Iridaceae family with a variety therapeutic potential that is widely cultivated in Southeast Asia. The bulb has been used traditionally among the Dayak community as a folk medicine to treat several diseases like diabetes, breast cancer, nasal congestion, and fertility problems. The bulb is exceptionally rich in phytochemicals like phenolic and flavonoid derivatives, naphthalene, anthraquinone, and naphthoquinone. The electronic database was searched using various keywords, i.e., E. bulbosa, E. americana, E. palmifolia, E. platifolia, and others due to the interchangeably used scientific names of different countries. Scientific investigations revealed that various pharmacological activities were recorded from the bulb of E. bulbosa including anti-cancer, anti-diabetic, anti-bacterial, anti-fungi, anti-viral, anti-inflammatory, dermatological problems, anti-oxidant, and anti-fertility. The potential application of the bulb in the food industry and in animal nutrition was also discussed to demonstrate its great versatility. This is a compact study and is the first study to review the extensive pharmacological activities of the E. bulbosa bulb and its potential applications. The development of innovative food and pharma products from the bulb of E. bulbosa is of great interest. Full article
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Graphical abstract

Review
Biological Properties and Prospects for the Application of Eugenol—A Review
Int. J. Mol. Sci. 2021, 22(7), 3671; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22073671 - 01 Apr 2021
Cited by 1 | Viewed by 638
Abstract
Eugenol is a phenolic aromatic compound obtained mainly from clove oil. Due to its known antibacterial, antiviral, antifungal, anticancer, anti-inflammatory and antioxidant properties, it has long been used in various areas, such as cosmetology, medicine, and pharmacology. However, high concentrations can be toxic. [...] Read more.
Eugenol is a phenolic aromatic compound obtained mainly from clove oil. Due to its known antibacterial, antiviral, antifungal, anticancer, anti-inflammatory and antioxidant properties, it has long been used in various areas, such as cosmetology, medicine, and pharmacology. However, high concentrations can be toxic. A dose of 2.5 mg/kg body weight is regarded as safe. This paper reviews the current state of knowledge regarding the activities and application of eugenol and its derivatives and recent research of these compounds. This review is based on information concerning eugenol characteristics and recent research from articles in PubMed. Eugenol remains of great interest to researchers, since its multidirectional action allows it to be a potential component of drugs and other products with therapeutic potential against a range of diseases. Full article
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Figure 1

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