Special Issue "Bioenergetics, Mitochondrial Dynamics and Cardiac Disease"
Deadline for manuscript submissions: 31 December 2021.
Interests: molecular mechanisms underlying cardiac dysfunction in disease; ischemia/reperfusion injury; heart failure; oxidative stress; intracellular signaling; redox signaling; metabolic regulation; mitochondrial function.
Interests: induced pluripotent stem cells (iPSCs); cardiovascular disease modeling and drug discovery; cardiometabolic disorders; cardiac bioenergetics; cell signaling and transcription factors in cardiogenesis.
Cardiovascular diseases remain the leading cause of death and disability worldwide despite the progress made over the past three decades in the prevention, diagnosis, and management of the disease. Thus, there is a substantial need to find novel approaches that could specifically address repair and regeneration of damaged and/or lost myocardium.
Cardiac disease is associated with metabolic changes that cause a progressive impairment of cardiac muscle high-energy phosphate production with further maladaptive effects. Advances in animal models and systems-based approaches have revealed that mitochondria have diverse functions beyond bioenergetics, and the ability to adapt and respond to a plethora of cellular and tissue-specific stimuli. Mitochondrial dysfunction has been identified as a key perturbation underlying numerous pathologies including heart failure and metabolic disorders. Emerging evidence highlights the connection between mitochondrial biology and changes in cardiac metabolism and their importance for cell survival and/or the progress of cardiac pathology.
This Special Issue will bring together reviews and original articles addressing the molecular signaling that connects metabolism and energy-sensing with mitochondrial function, and the roles of basic mitochondrial processes in metabolism and cardiac dysfunction. Identification of therapeutic targets and the development of novel approaches to treat cardiac diseases will be also a relevant aspect of this issue.Prof. Antigone Lazou
Dr. Chrishan J.A. Ramachandra
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Heart failure
- Ischemia/reperfusion injury
- Myocardial infarction
- Oxidative stress
- Cell metabolism
- Metabolic diseases
- Energy homeostasis
- Mitochondrial dynamics
- mitochondrial fusion
- mitochondrial fission
- mitochondrial biogenesis