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Special Issue "Biologically Active Substances in Cardiovascular and Neurological Diseases (Volume II)"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Prof. Dr. Ok-Nam Bae
E-Mail Website
Guest Editor
College of Pharmacy, Hanyang University, Ansan, Korea
Interests: xenobiotic-associated cerebrovascular damage; ischemic stroke; diabetic vascular dysfunction; drug development
Special Issues and Collections in MDPI journals
Prof. Dr. Arshad Majid
E-Mail Website
Guest Editor
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Interests: neuroprotection and neuroregeneration; electroceuticals; stroke clinical trials; animal and cellular models of stroke and neuroinflammation; novel drug delivery (nanotechnology and exosomes)
Special Issues and Collections in MDPI journals
Prof. Dr. G. K. Rajanikant
E-Mail Website
Guest Editor
School of Biotechnology, National Institute of Technology Calicut, Clicut, India
Interests: structure-based drug design and discovery; pharmacophore; network biology; molecular modelling
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue follows the publication of the first edition on “Biologically Active Substances in Cardiovascular and Neurological Disease”, which presented 13 high-quality papers.

The incidence and prevalence of chronic diseases such as heart disease and diabetes, and neurodegenerative diseases such as Alzheimer’s disease, have been increasing throughout the world. This trend coincides with changes in lifestyle and chronic exposure to risk factors including environmental pollutants. Interestingly, there has been increasing attention regarding a connection between the heart and the brain, and current evidence supports an association between cardiovascular (heart diseases, diabetes, stroke, and vascular diseases) and neurological diseases (neurovascular and neurodegenerative diseases).

The number of studies on naturally occurring bioactive substances has risen exponentially in recent decades, especially regarding their protective effects against oxidant stress or inflammatory signalling, which are the common underlying mechanisms for various chronic diseases, including cardiovascular and neurological diseases. The characterisation of the specific modes of action of bioactive substances in targeting certain pathological processes in specific diseases has also received much attention. Derivatisation or pharmaceutical modification of the original natural compounds are important approaches to increase the bioactivity of naturally occurring substances. Bioactive substances in foods, such as nutraceuticals, can also be promising agents to study, considering their role in the maintenance of homeostasis in health.

This Special Issue will cover a selection of research papers and reviews that expand knowledge about the potential of naturally occurring bioactive compounds in health and chronic diseases, specifically focusing on the cardiovascular and neurological diseases. We also welcome studies on the elucidation of bioactive mechanisms of natural products against these diseases, enhancement of bioactivity via pharmaceutical formulation or derivatisation of known bioactive substances, as well as on the identification of novel bioactive compounds.

Prof. Dr. Ok-Nam Bae
Prof. Dr. Arshad Majid
Prof. Dr. G. K. Rajanikant
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic diseases
  • natural products
  • bioactive substances
  • nutraceuticals
  • drug discovery
  • derivatives of natural substances
  • pharmaceutical formulation of bioactive substances

Published Papers (1 paper)

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Potential of Vasoprotectives to Inhibit Non-Enzymatic Protein Glycation, and Reactive Carbonyl and Oxygen Species Uptake
Int. J. Mol. Sci. 2021, 22(18), 10026; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms221810026 - 16 Sep 2021
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Reactive carbonyl species (RCS) such as methylglyoxal (MGO) or glyoxal (GO) are the main precursors of the formation of advanced glycation end products (AGEs). AGEs are a major factor in the development of vascular complications in diabetes. Vasoprotectives (VPs) exhibit a wide range [...] Read more.
Reactive carbonyl species (RCS) such as methylglyoxal (MGO) or glyoxal (GO) are the main precursors of the formation of advanced glycation end products (AGEs). AGEs are a major factor in the development of vascular complications in diabetes. Vasoprotectives (VPs) exhibit a wide range of activities beneficial to cardiovascular health. The present study aimed to investigate selected VPs and their structural analogs for their ability to trap MGO/GO, inhibit AGE formation, and evaluate their antioxidant potential. Ultra-high-performance liquid chromatography coupled with an electrospray ionization mass spectrometer (UHPLC-ESI-MS) and diode-array detector (UHPLC-DAD) was used to investigate direct trapping capacity and kinetics of quenching MGO/GO, respectively. Fluorimetric and colorimetric measurements were used to evaluate antiglycation and antioxidant action. All tested substances showed antiglycative effects, but hesperetin was the most effective in RCS scavenging. We demonstrated that rutin, diosmetin, hesperidin, and hesperetin could trap both MGO and GO by forming adducts, whose structures we proposed. MGO-derived AGE formation was inhibited the most by hesperetin, and GO-derived AGEs by diosmetin. High reducing and antiradical activity was confirmed for quercetin, rutin, hesperetin, and calcium dobesilate. Therefore, in addition to other therapeutic applications, some VPs could be potential candidates as antiglycative agents to prevent AGE-related complications of diabetes. Full article
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