Special Issue "Molecular Mechanisms of Biomineralization in Healthy and Pathological Bone Tissues"
Deadline for manuscript submissions: 31 December 2021.
Interests: X-Ray synchrotron-based techniques; biomineralization; osteoblastic differentiation; 3D cell culture; cellular imaging
Biomineralization refers to the process by which living systems generate organized mineral crystals. It represents an extremely widespread phenomenon culminating with hydroxyapatite formation. Biomineralization is a lifelong process, playing a key role in bone formation, repair, and remodeling. Bone mineralization depends upon the complex crosstalk between osteoclasts, osteoblasts, and osteocytes. The complexity of bone organization can be tackled across multiple length scales, and this structural hierarchy governs its mechanical behavior. The degree of bone mineralization, assessed by the bone mineral density, the microarchitecture, and the characteristics of the mineral deposits (apatite crystals), is a major determinant of bone quality. This whole set of determinants has to be taken into account and assessed if one intends to better understand and characterize bone “quality”. In that respect, further studies should be designed to characterize the molecular mechanisms involved in bone formation, repair, and remodeling. This Special Issue will be dedicated to “Molecular Mechanisms of Biomineralization in Healthy and Pathological Bone Tissues” with a focus on the mechanisms of bone formation and remodeling in both physiological and pathological conditions and the corresponding impact on bone quality. This Special Issue is intended to gather papers addressing various issues related to the assessment of bone quality in the fields of imaging, bioinformatics, cell differentiation, and regenerative medicine.
Prof. Emil Malucelli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- New Approaches and Tools to Study Bone
- 3D Cell Culture
- Regenerative Medicine
- Mesenchymal Stem Cell Differentiation
- Bone Diseases