Special Issue "Brain Diseases: on Signaling Pathways and Miswired Networks"
Deadline for manuscript submissions: closed (30 April 2021).
The purpose of this Special Issue entitled “Brain Diseases: on Signaling Pathways and Miswired Networks” is to discuss some of the recent advances in the use of genetic technology in the discovery of different interplayed/novel signaling pathways implicated in the altered neuronal networks involved in the pathogenesis of intellectual disabilities (IDs: Down/Rett/ Fragile X or DiGeorge syndrome) and various neurodegenerative diseases (NDs: Alzheimer’s/Parkinson’s/Huntington’s/Creutzfeldt–Jacob/Pick/ALS disorders), but not limited to these. Although pathologically, both ID and ND are deficits of neuronal network connectivity caused by signaling/genetic factors and both have presented common altered neuronal network structures, NDs are considered as ageing-associated disorders and are attributed to the accumulation/aggregation of pathogenic proteins while IDs are neurodevelopmental disorders associated with gene mutations/chromosome deletions/rearrangements that can be diagnosed in children aged 0 to 5 years. On the other hand, the sequencing of human genome identified ~30,000 genes, suggesting that the complex functional phenotype of an individual is not only directly related to the number of coding candidate genes but also on the genomic/proteomic-interactomic networks, the epigenetic factors, and the non-linear crosstalk between them. Consequently, it is important to highlight the interaction between different molecular levels and how this contributes to the functional diversity in different time periods, from birth to ageing. Finally, because of the scarcity of post-mortem brain patients and the important ethical regulation, we would also cover studies with transgenic animal models. They frequently make it possible to identify a single gene (dys)function, and help to decipher/explore the detailed genetic processes underlying disease pathogenesis or to rescue abnormalities through experimental gene transfer.
This Special Issue welcomes review/original manuscripts highlighting the molecular mechanisms and/or the multi-omics analyses of genetic-rejuvenation/-protection/-treatments of ID/ND using in vitro cultured cells, in vivo animal models, and in clinical settings. These approaches may provide novel/good references for future network studies and treatment as well.
Dr. Tam Thanh Quach
Manuscript Submission Information
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- neurodegenerative/neurodevelopment disorders
- neuronal networks
- transgenic animals
- gene identification/transfer/therapy
- chromosomal rearrangement/deletion
- cognitive deficit