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Special Issue "Brain/Mind Activity and Molecular Dynamics in Biological Systems"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Giuseppe Vitiello
E-Mail Website
Guest Editor
University of Salerno and INFN, Salerno, Italy
Interests: elementary particle physics; condensed matter; quantum field theory; fractals; coherent states; mathematical models of brain; biological systems
Dr. Carlo Dal Lin
E-Mail Website
Co-Guest Editor
Department of Cardiac, Thoracic and Vascular Sciences, Padua University School of Medicine, Via Giustiniani 2, 35100 Padua, Italy.
Interests: Integrative cardiology; Relaxation response; Psycho-neuro-endocrine immunology

Special Issue Information

Dear Colleagues,

There is much knowledge about the individual components that make up the human biological system but still very little is known about the dialogue between them. From the mutual interaction of different molecules and physical forces, properties extraneous to the single components of the system emerge. This is similar to what happens in physics where, for example, a crystal cannot be described solely by its constituent atoms. The crystal properties are described also in terms of the collective dynamical modes of the atoms, i.e., the phonons, plasmons, etc. These modes disappear when the crystal is split into its component atoms. However, crystal properties cannot emerge from the study of individual atoms considered one by one.

In brain studies, such a need of merging the atomist and dynamical views has been stressed since the forties by Karl Lashley who, based on observations in his laboratory, recognized that “nerve impulses are transmitted [...] from cell to cell through definite intercellular connections. Yet, all behavior seems to be determined by masses of excitation [...] within general fields of activity, without regard to particular nerve cells”.

This IJMS Special Issue is devoted to works, articles, or reviews aimed at merging the properties of individual molecules in biological systems with their dynamical interplay in the “living and thinking human being”. The aim is to provide a vision of the already known and possible interactions that link the functioning of the brain with other organs and the continuum of cells immersed in their aqueous environment that is rich in polar molecules in constant reciprocal interaction and as dissipative systems open to the environment.

Prof. Dr. Giuseppe Vitiello
Guest Editor
Dr. Carlo Dal Lin
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • molecular biology
  • system biology
  • cell
  • nervous cell
  • brain
  • neurobiology
  • brain modeling
  • psycho-neuroendocrine immunology
  • molecular dynamics
  • quantum field theory

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

“Transition between random and periodic electron currents on a DNA chain”

Elham Faraji, Roberto Franzosi, Stefano Mancini and Marco Pettini

 Abstract: By resorting to a model inspired to the standard Davydov and Holstein-Frohlich models, 

in the present paper we study the motion of an electron along a chain of heavy particles 

modelling a sequence of nucleotides proper to a DNA fragment. Starting with a model 

Hamiltonian written in second quantization, we use the Time Dependent Variational Principle 

to work out the dynamical equations of the system. It is found that under the action of an 

external source of energy transferred to the electron, below some threshold energy value the 

electron current displays a broad frequency spectrum whereas above this threshold the electron 

current is periodic and displays a sharply peaked frequency spectrum. This phenomenology is 

suggestive of a potentially rich variety of electrodynamic interactions of DNA molecules under the 

action of electron excitation. This could imply the activation of interactions between DNA and 

transcription factors, or between DNA and external electromagnetic fields.

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