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New Advance in Breast Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 3414

Special Issue Editor


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Guest Editor
Inserm U1052, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon, France
Interests: breast cancer; estrogen receptor; progesterone receptor; cell signaling; arginine methylation; arginine demethylation; post translational modifications; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Breast cancer is the second most common cancer and the fifth deadliest in the world, still representing a major health challenge. Even if targets have largely improved patient survival, development of resistance has led to the identification of drivers of this phenomena, however, new targeted therapies are being developed in order to offer more therapeutic options, and to circumvent the problem of resistance.

This Special Issue “New Advances in Breast Cancer” will provide an updated overview covering molecular mechanisms and all aspects of targeted therapies in breast cancer, from the basic science to the clinical trials. This Special Issue “New Advances in Breast Cancer” will provide an updated overview covering all aspects of targeted therapies in breast cancer, from the basic science to the clinical trials. There will be a special focus on new promising drugs as well as on potential biomarkers that are predictive for a therapeutic response.

Dr. Muriel Le Romancer
Guest Editor

Manuscript Submission Information

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Keywords

  • breast cancer
  • steroid receptors
  • cell signaling
  • protein kinases
  • targeted therapy
  • resistance
  • biomarkers

Published Papers (1 paper)

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Review

11 pages, 696 KiB  
Review
Targeting AKT in ER-Positive HER2-Negative Metastatic Breast Cancer: From Molecular Promises to Real Life Pitfalls?
by Benoîte Mery, Coralie Poulard, Muriel Le Romancer and Olivier Trédan
Int. J. Mol. Sci. 2021, 22(24), 13512; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222413512 - 16 Dec 2021
Cited by 6 | Viewed by 2815
Abstract
The AKT protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a therapeutic target, especially in hormone receptor-positive (HR) breast cancers, where the PI3K/AKT signaling pathway is largely hyperactivated. Moreover, [...] Read more.
The AKT protein kinase plays a central role in several interconnected molecular pathways involved in growth, apoptosis, angiogenesis, and cell metabolism. It thereby represents a therapeutic target, especially in hormone receptor-positive (HR) breast cancers, where the PI3K/AKT signaling pathway is largely hyperactivated. Moreover, resistance to therapeutic classes, including endocrine therapy, is associated with the constitutive activation of the PI3K/AKT pathway. Improved knowledge on the molecular mechanisms underlying resistance to endocrine therapy has led to the diversification of the therapeutic arsenal, notably with the development of PI3K and mTOR inhibitors, which are currently approved for the treatment of advanced HR-positive breast cancer patients. AKT itself constitutes a novel pharmacological target for which AKT inhibitors have been developed and tested in clinical trials. However, despite its pivotal role in cell survival and anti-apoptotic mechanisms, as well as in endocrine therapy resistance, few drugs have been developed and are available for clinical practice. The scope of the present review is to focus on the pivotal role of AKT in metastatic breast cancer through the analysis of its molecular features and to discuss clinical implications and remaining challenges in the treatment of HR-positive metastatic breast cancer. Full article
(This article belongs to the Special Issue New Advance in Breast Cancer)
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