Special Issue "Molecular Mechanisms Related to Burns, Burn Wound Healing and Scarring"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 February 2021).
Interests: burn; trauma; stress response; inflammation; hypermetabolism, including insulin resistance; cell regeneration; gene transfer; stem cells
Interests: inflammation; wound healing; fibrosis; tissue regeneration; ageing; immunity; antioxidants; obesity
Burn injury is a complex traumatic event with various local, regional and systemic effects. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, the inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury, and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care-related research. Conversely, inflammation is a necessary component in the later-stage processes of wound healing. Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now, up to 70% of patients develop hypertrophic scars after burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. Approaches to optimizing the healing potential of burn wounds use targeted wound care and surgery to minimize the development of hypertrophic scarring. Such approaches often fail, and modulation of the established scar is continued, although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimization of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventive and therapeutic strategies. In this issue of the journal, we are looking for articles which deliver a profound insight into the current science of burn wound pathophysiology, burn wound healing, and scarring.
Prof. Dr. Marc Jeschke
Prof. Dr. Lars-Peter Kamolz
Manuscript Submission Information
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- burn injury
- wound healing
- molecular mechanism