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Special Issue "Cyclic Nucleotides, Phosphodiesterases, and Cancer"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Gary A. Piazza
E-Mail Website
Guest Editor
Harrison School of Pharmacy Cancer Research Center, Auburn University, Auburn, AL, USA
Interests: cyclic GMP; phosphodiesterase; RAS; drug discovery; sulindac; NSAIDs
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

The impact of cyclic nucleotides such as cAMP or cGMP on normal and cancer cell growth has long been recognized. However, downstream signaling pathways that are either activated or suppressed by cyclic nucleotides that mediate growth regulation or are essential for growth have not been well defined. Multiple lines of evidence suggest that cyclic nucleotides can suppress key oncogenic signaling pathways resulting from mutations in various pathway components, including RAS and β-catenin. However, no anticancer drugs have been approved, or are on the horizon, that target cyclic nucleotide levels despite numerous publications reporting that the expression of various cyclic nucleotide phosphodiesterases is altered during malignant progression. This Special Issue will highlight publications from investigators in the cancer field studying cyclic nucleotides and phosphodiesterases and exchange information essential for target validation and pathway elucidation. The goal is to accelerate the discovery and development of new anticancer drugs that target cyclic nucleotide signaling pathways involved in cancer initiation, promotion, or progression.

Prof. Dr. Gary A. Piazza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cyclic AMP
  • Cyclic GMP
  • Phosphodiesterase
  • Cancer
  • Inhibitor
  • Adenylate cyclase
  • Guanylate cyclase
  • PDE10
  • PDE5

Published Papers

This special issue is now open for submission.
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