Special Issue "Recent Advances of Neural Networks: From Molecular Mechanisms to Therapeutic Exploitation"
Deadline for manuscript submissions: 30 November 2021.
We studied the role of individual extracellular matrix (ECM) molecules in the plasticity of vestibular or balance system in animal experiments. Our major results were that: (1) Damage to the vestibular receptors with unilateral labyrinthectomy (UL) and subsequent functional restoration is accompanied by the modification of brevican (one of the key molecules of ECM) expression in the perineuronal nets (PNNs) of superior vestibular nucleus in rat to ensure the establishment of new synaptic contacts. The bilateral changing in the brevican expression supports the involvement of commissural vestibular fibers in the vestibular compensation. (2) In the vestibular nuclei-related red nucleus and pararubral area, the expression pattern of PNNs is related with the cell size independently from the neuronal position within their subdivisions but it is associated with the functional properties of neurons. (3) In the visuomotor nuclei of brainstem only the singly innervating motoneurons are surrounded with PNNs. (4) In the developing vestibular nuclei and related structures the ECM is found in the neuropil, PNNs appear on the seventh postnatal day. (5) In the olfactory bulb, disorder of which is frequently observed in the vestibular disorders, the ECM molecules are shown dominantly in the neuropil, PNNs are rarely present. Our results may contribute to the development of ECM-targeting drugs applied in the vestibular disorders
Dr. Klára Matesz
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- vestibular system
- extracellular matrix
- developmental neuroscience
- human neuroanatomy
- cranial nerve nuclei
- electron microscopy