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Special Issue "Circulating Tumor Cells: From Research to Therapeutic Application"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Dario Marchetti
E-Mail Website
Guest Editor
1. Division of Molecular Medicine, Department of Internal Medicine, The University of New Mexico Health Sciences Center, Albuquerque, NM 87102, USA
2. Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, NM 87102, USA
3. Full Member, UNM Comprehensive Cancer Center, Albuquerque, NM 87102, USA
Interests: the biology and therapeutic utility of circulating tumor cells (CTCs); liquid biopsies; mechanisms of brain metastasis and dormancy in breast and melanoma cancers; molecular crosstalks between dormant bone-marrow (BM) cells and CTCs; roles of BM and BM cellular heterogeneity interplaying with metastasis and dormancy
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Special Issue Information

Dear Colleagues,

Circulating Tumor Cells (CTCs) comprise a rare and heterogeneous cell population that sheds from tumors and traverses the peripheral blood stream throughout the carcinogenic process, from early pre-malignant lesions to fatal metastasis. The concept of “Liquid Biopsy”-interrogating CTCs and other blood analytes (ctDNA, exosomes, microRNAs, etc.) for clinical application as precision medicine tools has significantly expanded in the last two decades, following the first implementation of liquid biopsy and proving the clinical utility of CTCs as independent prognostic indicators of progression-free and overall survival of metastatic cancer patients. Since then, the field of “Liquid Biopsy” has witnessed not only the development and commercialization of multiple platforms and tests, but also increased knowledge characterizing CTC biology, CTC subsets and CTC biomarkers. These advances have resulted in CTC analyses employing enrichment platforms that either capture CTCs by multiple parameters, at single-cell level, or that identify CTCs based on the expression of cancer-specific biomarkers or the presence of CTC-specific transcripts. Collectively, CTC studies have opened new investigational avenues towards the detection and prognostication of cancer progression and responses to therapy.

The objective of this Special Issue on CTCs is to publish the latest advances interrogating the biology and clinical implementation of CTCs. Contributions from diverse fields of expertise that outline the latest discoveries in CTC basic and translational research, including biological, genetic, technical, mathematical, pre-clinical and clinical advances, are welcome.

Prof. Dr. Dario Marchetti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis
Int. J. Mol. Sci. 2021, 22(13), 6993; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22136993 - 29 Jun 2021
Cited by 1 | Viewed by 978
Abstract
Up to 40% of advance lung, melanoma and breast cancer patients suffer from brain metastases (BM) with increasing incidence. Here, we assessed whether circulating tumor cells (CTCs) in peripheral blood can serve as a disease surrogate, focusing on CD44 and CD74 expression as [...] Read more.
Up to 40% of advance lung, melanoma and breast cancer patients suffer from brain metastases (BM) with increasing incidence. Here, we assessed whether circulating tumor cells (CTCs) in peripheral blood can serve as a disease surrogate, focusing on CD44 and CD74 expression as prognostic markers for BM. We show that a size-based microfluidic approach in combination with a semi-automated cell recognition system are well suited for CTC detection in BM patients and allow further characterization of tumor cells potentially derived from BM. CTCs were found in 50% (7/14) of breast cancer, 50% (9/18) of non-small cell lung cancer (NSCLC) and 36% (4/11) of melanoma patients. The next-generation sequencing (NGS) analysis of nine single CTCs from one breast cancer patient revealed three different CNV profile groups as well as a resistance causing ERS1 mutation. CD44 and CD74 were expressed on most CTCs and their expression was strongly correlated, whereas matched breast cancer BM tissues were much less frequently expressing CD44 and CD74 (negative in 46% and 54%, respectively). Thus, plasticity of CD44 and CD74 expression during trafficking of CTCs in the circulation might be the result of adaptation strategies. Full article
(This article belongs to the Special Issue Circulating Tumor Cells: From Research to Therapeutic Application)
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