Special Issue "Circulating Tumor Cells: From Research to Therapeutic Application"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2021.
2. Department of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, NM 87102, USA
3. Full Member, UNM Comprehensive Cancer Center, Albuquerque, NM 87102, USA
Interests: the biology and therapeutic utility of circulating tumor cells (CTCs); liquid biopsies; mechanisms of brain metastasis and dormancy in breast and melanoma cancers; molecular crosstalks between dormant bone-marrow (BM) cells and CTCs; roles of BM and BM cellular heterogeneity interplaying with metastasis and dormancy
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: Brain Metastasis 2014
Special Issue in International Journal of Molecular Sciences: Circulating Tumor Cells
Special Issue in International Journal of Molecular Sciences: Brain Metastasis 2016
Special Issue in Diagnostics: Circulating Tumor Cells as Cancer Diagnostic Biomarkers
Special Issue in Cancers: Circulating Tumor Cells (CTCs)
Special Issue in Cancers: Roles of the Tumor Microenvironment on Liquid Biopsy
Circulating Tumor Cells (CTCs) comprise a rare and heterogeneous cell population that sheds from tumors and traverses the peripheral blood stream throughout the carcinogenic process, from early pre-malignant lesions to fatal metastasis. The concept of “Liquid Biopsy”-interrogating CTCs and other blood analytes (ctDNA, exosomes, microRNAs, etc.) for clinical application as precision medicine tools has significantly expanded in the last two decades, following the first implementation of liquid biopsy and proving the clinical utility of CTCs as independent prognostic indicators of progression-free and overall survival of metastatic cancer patients. Since then, the field of “Liquid Biopsy” has witnessed not only the development and commercialization of multiple platforms and tests, but also increased knowledge characterizing CTC biology, CTC subsets and CTC biomarkers. These advances have resulted in CTC analyses employing enrichment platforms that either capture CTCs by multiple parameters, at single-cell level, or that identify CTCs based on the expression of cancer-specific biomarkers or the presence of CTC-specific transcripts. Collectively, CTC studies have opened new investigational avenues towards the detection and prognostication of cancer progression and responses to therapy.
The objective of this Special Issue on CTCs is to publish the latest advances interrogating the biology and clinical implementation of CTCs. Contributions from diverse fields of expertise that outline the latest discoveries in CTC basic and translational research, including biological, genetic, technical, mathematical, pre-clinical and clinical advances, are welcome.
Prof. Dr. Dario Marchetti
Manuscript Submission Information
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